Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
J Am Chem Soc. 2013 Sep 25;135(38):14012-5. doi: 10.1021/ja405919z. Epub 2013 Sep 16.
A practical, palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is presented. The reaction is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism suggests a single-electron-transfer pathway, involving a Pd(III) intermediate that has been isolated and characterized.
本文报道了一种从芳基硼酸衍生物制备芳基氟化物的实用钯催化合成方法。该反应操作简单，适用于大规模合成。反应机理的研究表明，该反应经历了单电子转移过程，涉及到一个已被分离和表征的 Pd(III) 中间体。
