• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Self-tolerance to HLA focuses the response of immunized HLA-transgenic mice on production of antibody to precise polymorphic HLA alloantigens.对HLA的自身耐受性使免疫的HLA转基因小鼠的反应集中于产生针对精确多态性HLA同种异型抗原的抗体。
Proc Natl Acad Sci U S A. 1990 Jan;87(1):235-9. doi: 10.1073/pnas.87.1.235.
2
HLA antibody responses in HLA class I transgenic mice.HLA I类转基因小鼠中的HLA抗体反应。
Immunogenetics. 1990;32(5):351-60. doi: 10.1007/BF00211650.
3
Cell-surface expression and alloantigenic function of a human nonclassical class I molecule (HLA-E) in transgenic mice.人非经典I类分子（HLA-E）在转基因小鼠中的细胞表面表达及同种抗原功能
J Immunol. 1999 May 1;162(9):5190-6.
4
Expression and immunogenicity of HLA-B27 in high-transfection recipient P815: a new method to induce monoclonal antibodies directed against HLA-B27.
Tissue Antigens. 1989 May;33(5):511-9. doi: 10.1111/j.1399-0039.1989.tb01702.x.
5
Induction of xenogeneic neonatal tolerance to transgenic human leukocyte antigen class I grafts.诱导对转基因人类白细胞抗原I类移植物的异种新生耐受。
Transplantation. 2004 Sep 27;78(6):844-52. doi: 10.1097/01.tp.0000136965.22023.60.
6
Analysis of xenoantigenicity of HLA class I molecules by a complete series of human-mouse hybrid genes.通过一系列完整的人-鼠杂交基因分析HLA I类分子的异种抗原性。
Transplantation. 1989 Jul;48(1):135-40. doi: 10.1097/00007890-198907000-00031.
7
Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice.HLA-Cw3转基因小鼠中HLA-C抗原的免疫功能
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5664-8. doi: 10.1073/pnas.85.15.5664.
8
Specificity and frequency of primary anti-HLA cytotoxic T lymphocytes in normal and HLA-B27.2-, HLA-B27.5-, and HLA-Cw3-transgenic mice. A transgenic model for MHC xenoantigen recognition.正常及HLA - B27.2、HLA - B27.5和HLA - Cw3转基因小鼠中主要抗HLA细胞毒性T淋巴细胞的特异性和频率。一种MHC异种抗原识别的转基因模型。
J Immunol. 1990 Jun 15;144(12):4513-9.
9
Cell surface detection of HLA-E gene products with a specific monoclonal antibody.使用特异性单克隆抗体对HLA-E基因产物进行细胞表面检测。
J Reprod Immunol. 1999 Jul;43(2):195-201. doi: 10.1016/s0165-0378(99)00033-9.
10
Expression of an HLA-Bw6-related specificity by the HLA-Cw3 molecule.HLA - Cw3分子表达与HLA - Bw6相关的特异性。
Immunogenetics. 1985;21(5):469-78. doi: 10.1007/BF00430930.

引用本文的文献

1
Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.IgG 型自身反应性 B 细胞缺失和 Fas(lpr)狼疮小鼠缺陷。
J Immunol. 2010 Jul 15;185(2):1015-27. doi: 10.4049/jimmunol.1000698. Epub 2010 Jun 16.
2
Virus-induced maturation and activation of autoreactive memory B cells.病毒诱导自身反应性记忆B细胞的成熟与激活。
J Exp Med. 2000 Dec 18;192(12):1763-74. doi: 10.1084/jem.192.12.1763.
3
Activation and negative selection of functionally distinct subsets of antibody-secreting cells by influenza hemagglutinin as a viral and a neo-self antigen.流感血凝素作为病毒抗原和新自身抗原对功能不同的抗体分泌细胞亚群的激活和阴性选择。
J Exp Med. 1996 Jan 1;183(1):13-26. doi: 10.1084/jem.183.1.13.
4
HLA-B51 transgenic mice as recipients for production of polymorphic HLA-A, B-specific antibodies.HLA - B51转基因小鼠作为产生多态性HLA - A、B特异性抗体的受体。
Immunogenetics. 1993;37(2):139-42. doi: 10.1007/BF00216838.
5
HLA antibody responses in HLA class I transgenic mice.HLA I类转基因小鼠中的HLA抗体反应。
Immunogenetics. 1990;32(5):351-60. doi: 10.1007/BF00211650.

本文引用的文献

1
Gene transfer into mouse embryos: production of transgenic mice by pronuclear injection.基因导入小鼠胚胎：通过原核注射产生转基因小鼠。
Methods Enzymol. 1983;101:411-33. doi: 10.1016/0076-6879(83)01031-9.
2
HLA monoclonal antibody registry: second listing.人类白细胞抗原单克隆抗体登记处：第二次清单
Tissue Antigens. 1983 Aug;22(2):97-106. doi: 10.1111/j.1399-0039.1983.tb01175.x.
3
Transformation of murine LMTK- cells with purified HLA class I genes. I. Modification of conformation of murine beta 2-microglobulin upon its association with HLA heavy chains.用纯化的HLA I类基因转化小鼠LMTK-细胞。I. 小鼠β2-微球蛋白与HLA重链结合后构象的改变。
J Immunol. 1983 Mar;130(3):1432-8.
4
Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.Ly - A和Ly - B：小鼠淋巴细胞同种抗原的两个系统。
Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175-93. doi: 10.1098/rspb.1968.0032.
5
Nature of polymorphism in HLA-A, -B, and -C molecules.HLA - A、-B和-C分子多态性的本质。
Proc Natl Acad Sci U S A. 1988 Jun;85(11):4005-9. doi: 10.1073/pnas.85.11.4005.
6
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.转基因小鼠中免疫球蛋白表达的改变及自身反应性B淋巴细胞的功能沉默
Nature. 1988 Aug 25;334(6184):676-82. doi: 10.1038/334676a0.
7
Cell surface expression and alloantigenic function of a human class I MHC heavy chain gene (HLA-B7) in transgenic mice.人I类主要组织相容性复合体重链基因（HLA - B7）在转基因小鼠中的细胞表面表达及同种抗原功能
J Immunol. 1988 Feb 15;140(4):1285-92.
8
HLA-B locus polymorphism: studies with a specific hybridization probe.HLA - B 基因座多态性：使用特异性杂交探针的研究
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8614-8. doi: 10.1073/pnas.82.24.8614.
9
Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form.以可溶性形式表达外源移植抗原的转基因小鼠的同种异体反应性免疫应答。
Proc Natl Acad Sci U S A. 1988 Apr;85(7):2269-73. doi: 10.1073/pnas.85.7.2269.
10
Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice.HLA-Cw3转基因小鼠中HLA-C抗原的免疫功能
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5664-8. doi: 10.1073/pnas.85.15.5664.

对HLA的自身耐受性使免疫的HLA转基因小鼠的反应集中于产生针对精确多态性HLA同种异型抗原的抗体。

Self-tolerance to HLA focuses the response of immunized HLA-transgenic mice on production of antibody to precise polymorphic HLA alloantigens.

作者信息

Hämmerling G J, Chamberlain J W, Dill O, Yang S Y, Dupont B, Khan R, Chua R, Weissman S M, Hämmerling U

机构信息

Institute of Immunology and Genetics, West German Cancer Research Center, Heidelberg.

出版信息

Proc Natl Acad Sci U S A. 1990 Jan;87(1):235-9. doi: 10.1073/pnas.87.1.235.

DOI:10.1073/pnas.87.1.235
PMID:2404277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC53236/
Abstract

HLA class I-transgenic mice express HLA antigen on their tissues and establish self-tolerance to the expressed monomorphic and polymorphic determinants. When challenged with skin grafts and lymphoid cells of a second HLA-transgenic mouse expressing a different HLA molecule, a specific immune response is elicited that is focused on the determinants specified by the allelic HLA differences between donor and recipient transgenic mice. In the studies described, this has led to the production of a number of monoclonal antibodies with specificity for the HLA-Cw3 and HLA-B7 crossreactive groups of class I antigens. These results indicate that immunization of appropriate transgenic strains of mice with murine cells expressing a different HLA allelic transgene should permit the generation of monoclonal antibodies of narrow specificity against virtually any polymorphic epitope on HLA antigens.

摘要

HLA I类转基因小鼠在其组织上表达HLA抗原，并对所表达的单态性和多态性决定簇建立自身耐受性。当用表达不同HLA分子的第二只HLA转基因小鼠的皮肤移植物和淋巴细胞进行攻击时，会引发特异性免疫反应，该反应集中于供体和受体转基因小鼠之间等位基因HLA差异所指定的决定簇。在所描述的研究中，这已导致产生了许多对I类抗原的HLA-Cw3和HLA-B7交叉反应组具有特异性的单克隆抗体。这些结果表明，用表达不同HLA等位基因转基因的鼠细胞免疫适当的转基因小鼠品系，应该能够产生针对HLA抗原上几乎任何多态性表位的窄特异性单克隆抗体。