生长因子信号转导与记忆形成：分子网络的时空整合。
Growth factor signaling and memory formation: temporal and spatial integration of a molecular network.
机构信息
Center for Neural Science, New York University, New York, New York 10003, USA.
出版信息
Learn Mem. 2013 Sep 16;20(10):531-9. doi: 10.1101/lm.031377.113.
Growth factor (GF) signaling is critically important for developmental plasticity. It also plays a crucial role in adult plasticity, such as that required for memory formation. Although different GFs interact with receptors containing distinct types of kinase domains, they typically signal through converging intracellular cascades (e.g., Ras-MEK-MAPK) to mediate overlapping functional endpoints. Several GFs have been implicated in memory formation, but due to a high level of convergent signaling, the unique contributions of individual GFs as well as the interactions between GF signaling cascades during the induction of memory is not well known. In this review, we highlight the unique roles of specific GFs in dendritic plasticity, and discuss the spatial and temporal profiles of different GFs during memory formation. Collectively, the data suggest that the roles of GF signaling in long-lasting behavioral and structural plasticity may be best viewed as interactive components in a complex molecular network.
生长因子（GF）信号对于发育可塑性至关重要。它在成人可塑性中也起着关键作用，例如记忆形成所需的可塑性。尽管不同的 GF 与含有不同类型激酶结构域的受体相互作用，但它们通常通过收敛的细胞内级联（例如 Ras-MEK-MAPK）信号传导来介导重叠的功能终点。几种 GF 已被牵涉到记忆形成中，但由于高度收敛的信号传导，单个 GF 的独特贡献以及 GF 信号转导在记忆诱导期间的相互作用尚不清楚。在这篇综述中，我们强调了特定 GF 在树突可塑性中的独特作用，并讨论了不同 GF 在记忆形成过程中的时空特征。总的来说，这些数据表明，GF 信号在持久的行为和结构可塑性中的作用可能最好被视为复杂分子网络中的交互组件。
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