Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Jaczewskiego Street 8, 20-954, Lublin, Poland,
Inflammation. 2014 Feb;37(1):223-34. doi: 10.1007/s10753-013-9733-9.
Kynurenic acid (KYNA) is one of the end products of tryptophan metabolism. The aim of this study was to analyse plasma KYNA concentration in septic shock patients (SSP) with acute kidney injury (AKI) undergoing continuous veno-venous haemofiltration (CVVH). Changes in KYNA content were compared to alterations in the levels of procalcitonin (PCT), C-reactive protein and lactate. Adult SSP with AKI were examined. Measurements were conducted at seven time points: before beginning CVVH and at 6, 12, 24, 48, 72 and 96 h after the beginning of CVVH. Based on clinical outcomes, the data were analysed separately for survivors and non-survivors. Twenty-seven patients were studied. CVVH was associated with reduced plasma KYNA concentration only in survivors. Plasma KYNA concentration correlated with the levels of lactate and PCT only in survivors. (1) CVVH reduced plasma KYNA concentration only in survivors; (2) lack of this reduction may predict fatal outcomes in SSP.
犬尿氨酸（KYNA）是色氨酸代谢的终产物之一。本研究旨在分析行连续性静脉-静脉血液滤过（CVVH）的伴有急性肾损伤（AKI）的脓毒性休克患者（SSP）的血浆 KYNA 浓度。将 KYNA 含量的变化与降钙素原（PCT）、C 反应蛋白和乳酸水平的变化进行比较。对伴有 AKI 的成年 SSP 进行检查。在七个时间点进行测量：开始 CVVH 前和开始 CVVH 后 6、12、24、48、72 和 96 小时。根据临床结果，对存活者和非存活者的数据分别进行分析。共研究了 27 名患者。仅在存活者中，CVVH 与血浆 KYNA 浓度降低相关。仅在存活者中，血浆 KYNA 浓度与乳酸和 PCT 水平相关。（1）CVVH 仅在存活者中降低血浆 KYNA 浓度；（2）这种降低的缺乏可能预测 SSP 的致命结局。
