50岁及以上正常成年马来人的海马磁共振容积测定
MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above.
作者信息
Embong Muhammad Fadli, Yaacob Ruwaida, Abdullah Mohd Shafie, Abdul Karim Ahmad Helmy, Ghazali Anis Kausar, Jalaluddin Win Mar Salmah
机构信息
Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
出版信息
Malays J Med Sci. 2013 Jul;20(4):25-31.
BACKGROUND
Hippocampal volume is affected by several psychiatric illnesses of old age, as well as by normal aging. It is important to have a normal data in a population to assist in diagnosis. The aim of this study is to determine hippocampal volume in normal Malay people aged 50 years old and older.
METHODS
This was a cross-sectional study of the normal Malay population aged 50 to 77 years. We included 43 participants, representing 19 men and 24 women. Magnetic resonance imaging (MRI) was performed using a GE Signa Horizon LX 1.0 Tesla. Oblique coronal images of temporal lobes were obtained and hippocampal volumetry was done manually and normalised with intracranial volume.
RESULTS
Mean right and left hippocampal volumes (HCVs) were 3.43 cm³ (SD 0.32) and 3.26 cm³ (SD 0.34), with a significant difference between them (P < 0.001). Total mean HCVs exhibited no significant difference between men and women (P = 0.234). The means of the normalised right and left HCVs were 3.42 cm³ (SD 0.31) and 3.26 cm³ (SD 0.32).
CONCLUSION
The mean right and left hippocampal volumes were significantly different in this study. Men had slightly larger mean HCVs but the difference was not statistically significant. It was found that normalisation further reduces the mean volume difference between the genders.
背景
海马体体积受多种老年精神疾病以及正常衰老过程的影响。在人群中拥有正常数据对于辅助诊断很重要。本研究的目的是确定50岁及以上正常马来人群的海马体体积。
方法
这是一项对50至77岁正常马来人群的横断面研究。我们纳入了43名参与者，其中男性19名，女性24名。使用GE Signa Horizon LX 1.0特斯拉进行磁共振成像（MRI）。获取颞叶的斜冠状位图像，并手动进行海马体容积测量，并用颅内体积进行标准化。
结果
右侧和左侧海马体体积（HCV）的平均值分别为3.43 cm³（标准差0.32）和3.26 cm³（标准差0.34），两者之间存在显著差异（P < 0.001）。HCV的总平均值在男性和女性之间无显著差异（P = 0.234）。标准化后的右侧和左侧HCV平均值分别为3.42 cm³（标准差0.31）和3.26 cm³（标准差0.32）。
结论
在本研究中，右侧和左侧海马体的平均体积存在显著差异。男性的平均HCV略大，但差异无统计学意义。研究发现，标准化进一步缩小了两性之间的平均体积差异。
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