Kang Sungmin, Park Hyun Jun, Park Nam Cheol
Department of Urology, Pusan National University School of Medicine, Busan, Korea. ; Medical Research Institute, Pusan National University Hospital, Busan, Korea.
Korean J Urol. 2013 Sep;54(9):619-23. doi: 10.4111/kju.2013.54.9.619. Epub 2013 Sep 10.
Late-onset hypogonadism (LOH) in aging males is a clinical and biochemical syndrome characterized by a decline in serum testosterone levels. LOH results in various physical and mental disabilities. We evaluated the relationship between serum testosterone levels and symptoms of LOH.
During an andropause screening program, we examined responses to the Saint Louis university androgen deficiency in aging males (ADAM) questionnaire and results on the International Index of Erectile Function (IIEF-5) in terms of clinical symptoms and evaluated serum total testosterone levels for a biochemical diagnosis of LOH in healthy community-living volunteers aged over 40 years.
The mean age of the 534 men was 59.1 years (range, 40 to 79 years), and their mean serum testosterone level was 464.1±171.9 ng/dL. The serum testosterone level decreased significantly with age. There was a 92.5% positive response rate to the ADAM questionnaire. The percentage of patients whose serum testosterone level was <350 ng/dL among those with a positive response to the ADAM questionnaire was 25.6% (137 patients). The mean serum testosterone level among patients with a positive or negative ADAM questionnaire was 472.4±198.5 ng/dL and 487.3±165.7 ng/dL, respectively (p>0.05). There was no significant correlation between IIEF-5 scores and serum testosterone levels.
Among men over 40 years of age, 25.6% met the clinical and biochemical diagnostic criteria for LOH. There was no relationship between serum testosterone levels and symptoms of LOH.
老年男性迟发性性腺功能减退（LOH）是一种临床和生化综合征，其特征为血清睾酮水平下降。LOH会导致各种身心功能障碍。我们评估了血清睾酮水平与LOH症状之间的关系。
在一项更年期筛查项目中，我们根据临床症状检查了对圣路易斯大学老年男性雄激素缺乏症（ADAM）问卷的回答以及国际勃起功能指数（IIEF-5）的结果，并评估了40岁以上健康社区志愿者的血清总睾酮水平，以进行LOH的生化诊断。
534名男性的平均年龄为59.1岁（范围40至79岁），其平均血清睾酮水平为464.1±171.9 ng/dL。血清睾酮水平随年龄显著下降。ADAM问卷的阳性应答率为92.5%。在对ADAM问卷有阳性应答的患者中，血清睾酮水平<350 ng/dL的患者比例为25.6%（137例患者）。ADAM问卷阳性或阴性患者的平均血清睾酮水平分别为472.4±198.5 ng/dL和487.3±165.7 ng/dL（p>0.05）。IIEF-5评分与血清睾酮水平之间无显著相关性。
40岁以上男性中，25.6%符合LOH的临床和生化诊断标准。血清睾酮水平与LOH症状之间无关联。
