1 Department of Food and Biotechnology, Korea University , Seoul, Republic of Korea.
J Med Food. 2013 Sep;16(9):785-92. doi: 10.1089/jmf.2012.2663.
To find acetylcholinesterase (AChE) inhibitors for the prevention of neurological disorders, such as Alzheimer's disease, ethanol extracts of promising traditional edible Korean plants were tested. Among them, Rubus coreanus Miquel extract exhibited the most significant AChE inhibitory activity. The effect of R. coreanus extract on trimethyltin-induced memory impairment in mice was investigated using Y-maze and passive avoidance tests. Our results showed that administration of R. coreanus extract significantly improved alternation behavior and step-through latency. In addition, R. coreanus extract was sequentially fractionated, and the purified constituent was determined to be 3,4,5-trihydroxybenzoic acid.
为了寻找乙酰胆碱酯酶 (AChE) 抑制剂来预防神经紊乱，如阿尔茨海默病，对有前途的传统韩国食用植物的乙醇提取物进行了测试。其中，悬钩子属植物提取物表现出最显著的 AChE 抑制活性。用 Y 迷宫和被动回避试验研究了悬钩子属植物提取物对三甲基锡诱导的小鼠记忆障碍的影响。结果表明，悬钩子属植物提取物可显著改善交替行为和避错潜伏期。此外，悬钩子属植物提取物被顺序分级分离，纯化的成分被确定为 3,4,5-三羟基苯甲酸。
