Jung Kyung-Ah, Han Daeseok, Kwon Eun-Kyung, Lee Chang-Ho, Kim Young-Eon
Department of Practical Arts Education, Chuncheon National University of Education, Chuncheon, Republic of Korea.
J Med Food. 2007 Dec;10(4):689-93. doi: 10.1089/jmf.2006.006.
The antifatigue properties of six Korean medicinal herb extracts were studied by evaluating forced swimming capacity and biochemical parameters in ICR mice. The treatment groups were orally administered 30% ethanolic extracts (500 mg/kg/day) of Rubus coreanus Miquel, Cyperus rotundus Linn., Acanthopanax sessiliflorus, Saururus chinensis Baili, Epimedium koreanumNakai, or Houttuynia cordata Thunb. for 4 weeks. Swimming time to exhaustion was found to be longer for the group fed R. coreanus than for the control group (P < .05). No significant differences were found in the plasma levels of either glucose or lactate between the control group and the group fed R. coreanus, which swam longer than the control. The plasma ammonia levels were significantly lower in the groups fed R. coreanus and A. sessiliflorus, when compared to the control group (P < .05). No significant differences were found in gastrocnemius muscle or liver glycogen content between the control group and any treatment group. These results suggest that R. coreanus extract, and none of the other herbs, has antifatigue effects in mice, as demonstrated by the increased forced swimming capacity and decreased plasma ammonia accumulation.
通过评估ICR小鼠的强迫游泳能力和生化参数，研究了六种韩国草药提取物的抗疲劳特性。治疗组口服给予30%乙醇提取物（500毫克/千克/天）的悬钩子、香附、无梗五加、三白草、朝鲜淫羊藿或鱼腥草，持续4周。发现喂食悬钩子的组的游泳至疲劳时间比对照组更长（P < 0.05）。在对照组和游泳时间比对照组更长的喂食悬钩子的组之间，血浆葡萄糖或乳酸水平没有发现显著差异。与对照组相比，喂食悬钩子和无梗五加的组的血浆氨水平显著更低（P < 0.05）。在对照组和任何治疗组之间，腓肠肌或肝脏糖原含量没有发现显著差异。这些结果表明，悬钩子提取物而非其他草药具有抗疲劳作用，表现为强迫游泳能力增强和血浆氨积累减少。
