Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
World J Surg Oncol. 2013 Sep 17;11:234. doi: 10.1186/1477-7819-11-234.
Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare.
A 55-year-old male patient presented with an asymptomatic mass of the upper lip that had noticed 8 years previously. The mass was clinically suspected to be a benign salivary gland tumor based on palpation and magnetic resonance imaging findings. A needle biopsy was then carried out, and the pathological diagnosis was pleomorphic adenoma. The tumor was removed under general anesthesia. Histopathological examination revealed well-demarcated tumor tissues showing typical histologic features of pleomorphic adenoma. However, SCC tissue with several mitotic figures was found in the central area of the tumor tissue. The tumor was finally diagnosed as CXPA. There was no evidence of recurrence or metastasis 6 years postoperatively.
This is the first report of CXPA of the upper lip with an unusual malignant component of SCC.
发生在上唇的癌肉瘤（CXPA）中的鳞状细胞癌（SCC）作为恶性成分较为罕见。
一名 55 岁男性患者因 8 年前发现的无症状上唇肿块就诊。根据触诊和磁共振成像结果，临床怀疑该肿块为良性唾液腺肿瘤。随后进行了细针活检，病理诊断为多形性腺瘤。该肿瘤在全身麻醉下切除。组织病理学检查显示边界清楚的肿瘤组织，具有典型的多形性腺瘤组织学特征。然而，在肿瘤组织的中央区域发现了具有几个有丝分裂象的 SCC 组织。该肿瘤最终诊断为 CXPA。术后 6 年无复发或转移证据。
这是首例报道的发生在上唇的具有 SCC 这一不常见恶性成分的 CXPA。
