Umar Zaryab, Ilyas Usman, Alshamam Mohsen S, Foster Allison, Bhangal Rubal, Ahmed Nazaakat, Idrees Zarwa
Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA.
Internal Medicine, NYC Health + Hospitals, New York, USA.
Cureus. 2022 May 26;14(5):e25357. doi: 10.7759/cureus.25357. eCollection 2022 May.
Cancer is a major cause of morbidity and mortality worldwide, with squamous cell carcinoma (SCC) being the most common type. Even though SCC is the major type of cancer found in the head and neck region, the salivary glands contribute to about 1/20 cases, of which 1/10 are said to be carcinoma ex pleomorphic adenoma (CXPA) type, and the parotid gland is found to be the most common origin of such cases. Although it usually arises later in life, it can grow rapidly, with local symptoms being late findings, if any. Even though fine needle aspiration cytology has low sensitivity for diagnosing such cancer, multiple/repeated biopsies can increase the yield and the accuracy of the test. Surgical resection is the main choice for treatment with postoperative radiation for select cases. Our case presented with CXPA with distant metastasis to multiple sites.
癌症是全球发病和死亡的主要原因，其中鳞状细胞癌（SCC）是最常见的类型。尽管SCC是头颈部最主要的癌症类型，但唾液腺癌症约占所有病例的1/20，其中1/10据说为多形性腺瘤癌变（CXPA）类型，且腮腺是此类病例最常见的起源部位。虽然它通常在生命后期出现，但生长迅速，局部症状即使有也往往出现较晚。尽管细针穿刺细胞学检查对诊断此类癌症的敏感性较低，但多次/重复活检可提高检测的阳性率和准确性。手术切除是主要的治疗选择，部分病例术后需放疗。我们的病例为CXPA伴多部位远处转移。
