Umemori Koki, Ono Kisho, Kanemoto Hideka, Obata Kyoichi, Kawai Hotaka, Nakamura Tomoya, Nakano Keisuke, Ibaragi Soichiro, Nagatsuka Hitoshi, Sasaki Akira
Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Gland Surg. 2022 Oct;11(10):1730-1740. doi: 10.21037/gs-22-308.
Pleomorphic adenoma (PA) is the most frequent benign salivary gland tumor, but a lip PA is rare. Although this tumor may be definitively diagnosed by imaging or a tissue biopsy if it is reasonably large, PAs on the lip are relatively small, and they present findings that are similar to those of other lip lesions, which can make a preoperative diagnosis difficult.
We analyzed all PAs in the oral region and lesions on the lips treated in our department over the past 20 years, and we discuss them together with the relevant literature.
We found that 11.8% (n=6) of the PAs occurred on a lip (upper lip: 9.8%, lower lip: 2.0%), and ~1% of all mass lesions of the lips were PAs. The average size of the lip PAs was 1.5±0.7 cm (range, 0.7-2.2 cm). For preoperative diagnostic assistance, ultrasonography (US) (n=4), magnetic resonance (MR) (n=3), or no imaging (n=2) was used. An excisional biopsy was performed in all cases, and to date, no recurrence or malignant transformation has been observed.
Lip PA is relatively rare. Because almost all of these lesions are small, a preoperative diagnosis is more difficult compared to palatal lesions. This tumor is also prone to long-term neglect and has the potential for recurrence and malignant transformation. It is thus necessary to perform an excision that includes the capsule and surrounding tissues, and careful postoperative follow-up should be continued.
多形性腺瘤（PA）是最常见的涎腺良性肿瘤，但唇部PA较为罕见。尽管这种肿瘤如果体积足够大，可通过影像学检查或组织活检明确诊断，但唇部的PA相对较小，其表现与其他唇部病变相似，这使得术前诊断困难。
我们分析了过去20年在我科治疗的口腔区域所有PA及唇部病变，并结合相关文献进行讨论。
我们发现11.8%（n = 6）的PA发生在唇部（上唇：9.8%，下唇：2.0%），唇部所有肿块病变中约1%为PA。唇部PA的平均大小为1.5±0.7 cm（范围0.7 - 2.2 cm）。为辅助术前诊断，使用了超声检查（US）（n = 4）、磁共振成像（MR）（n = 3）或未进行影像学检查（n = 2）。所有病例均行切除活检，迄今为止，未观察到复发或恶变。
唇部PA相对罕见。由于几乎所有这些病变都较小，与腭部病变相比，术前诊断更困难。这种肿瘤也容易被长期忽视，有复发和恶变的可能。因此，有必要进行包括包膜和周围组织的切除，并应持续进行仔细的术后随访。
