Alagaratnam Swethan, Nathaniel Calvin, Cuckow Peter, Duffy Patrick, Mushtaq Imran, Cherian Abraham, Desai Divyesh, Kiely Edward, Pierro Agostino, Drake David, De Coppi Paolo, Cross Kate, Curry Joe, Smeulders Naima
Department of Paediatric Urology, Great Ormond Street Hospital NHS Foundation Trust, Great Ormond Street, London, UK.
Department of Paediatric Urology, University College London Hospitals NHS Foundation Trust, Euston Road, London, UK.
J Pediatr Urol. 2014 Feb;10(1):186-92. doi: 10.1016/j.jpurol.2013.08.005. Epub 2013 Aug 31.
To assess outcome after laparoscopic second-stage Fowler-Stephens orchidopexy (L2(nd)FSO).
Retrospective review of 94 children (aged 0.75-16 years, median 2.75 years), who underwent L2(nd)FSO for 113 intra-abdominal testes between January 2000 and May 2009: 75 unilateral, 19 bilateral (11 synchronous; 8 metachronous). Follow-up (range 3 months-10.9 years, median 2.1 years) was available for 88 children (102 testes: 71 unilateral, 31 bilateral).
Testicular atrophy occurred in 9 out of 102 (8.8%), including 8 out of 71 (11.3%) unilateral and 1 out of 31 (3.2%) bilateral intra-abdominal testes (multivariate analysis: p = 0.59). Testicular ascent ensued in 9 out of 102 (8.8%), comprising four (5.6%) unilateral and five (16.1%) bilateral testicles (multivariate analysis: p = 0.11). Of the 18 bilateral testes brought to the scrotum synchronously none atrophied and four (22.2%) ascended, compared to one (7.7%) atrophy and one (7.7%) ascent among the 13 testes brought to the scrotum on separate occasions (Fisher exact test: p = 0.42 and p = 0.37, respectively). Mobilization of the testis through the conjoint tendon tended towards less ascent (multivariate analysis p = 0.08) but similar atrophy (p = 0.56) compared to mobilization through the deep-ring/inguinal canal. Logistical regression analysis identified no other patient or surgical factors influencing outcome.
This is the largest series of L2(nd)FSO to date. A successful outcome is recorded in 85 out of 102 (83.3%) testicles. Atrophy occurred in 8.8% and ascent in 8.8%.
评估腹腔镜二期福勒-斯蒂芬斯睾丸固定术(L2(nd)FSO)后的治疗效果。
回顾性分析2000年1月至2009年5月间94例(年龄0.75 - 16岁,中位年龄2.75岁)因113个腹腔内睾丸接受L2(nd)FSO手术的儿童:75例单侧,19例双侧(11例同步;8例不同步)。88例儿童(102个睾丸:71个单侧,31个双侧)获得随访(范围3个月 - 10.9年,中位时间2.1年)。
102个睾丸中有9个(8.8%)发生睾丸萎缩,其中71个单侧腹腔内睾丸中有8个(11.3%),31个双侧腹腔内睾丸中有1个(3.2%)(多因素分析:p = 0.59)。102个睾丸中有9个(8.8%)睾丸上升,包括4个(5.6%)单侧和5个(16.1%)双侧睾丸(多因素分析:p = 0.11)。18个同步降至阴囊的双侧睾丸均未萎缩,4个(22.2%)上升,而13个分阶段降至阴囊的睾丸中有1个(7.7%)萎缩,1个(7.7%)上升(Fisher精确检验:分别为p = 0.42和p = 0.37)。与通过深环/腹股沟管游离睾丸相比,通过联合腱游离睾丸时睾丸上升倾向较小(多因素分析p = 0.08),但萎缩情况相似(p = 0.56)。逻辑回归分析未发现其他影响治疗效果的患者或手术因素。
这是迄今为止最大规模的L2(nd)FSO系列研究。102个睾丸中有85个(83.3%)治疗效果良好。萎缩发生率为8.8%,上升发生率为8.8%。