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1
Targeting the kidney in acute heart failure: can old drugs provide new benefit? Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE AHF) trial.急性心力衰竭时针对肾脏：老药能否带来新益处？急性心力衰竭肾脏优化策略评估（ROSE AHF）试验。
Circ Heart Fail. 2013 Sep 1;6(5):1087-94. doi: 10.1161/CIRCHEARTFAILURE.113.000347.
2
Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure).射血分数降低或保留的急性心力衰竭患者对小剂量多巴胺或小剂量奈西立肽的不同反应：ROSE AHF试验（急性心力衰竭肾优化策略评估）结果
Circ Heart Fail. 2016 Aug;9(8). doi: 10.1161/CIRCHEARTFAILURE.115.002593.
3
History of Atrial Fibrillation and Trajectory of Decongestion in Acute Heart Failure.心房颤动的历史与急性心力衰竭的去充血轨迹。
JACC Heart Fail. 2019 Jan;7(1):47-55. doi: 10.1016/j.jchf.2018.09.008. Epub 2018 Nov 5.
4
Acute decompensated heart failure: the shrinking role of inotropic therapy.急性失代偿性心力衰竭：正性肌力药物治疗的作用逐渐缩小
J Am Coll Cardiol. 2005 Jul 5;46(1):65-7. doi: 10.1016/j.jacc.2005.04.007.
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Is there still a role for low-dose dopamine use in acute heart failure?小剂量多巴胺在急性心力衰竭治疗中仍有作用吗？
Curr Opin Crit Care. 2014 Oct;20(5):467-71. doi: 10.1097/MCC.0000000000000133.
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Renal impairment and worsening of renal function in acute heart failure: can new therapies help? The potential role of serelaxin.肾功能损害和急性心力衰竭时肾功能恶化：新疗法是否有效？瑞那利辛的潜在作用。
Clin Res Cardiol. 2015 Aug;104(8):621-31. doi: 10.1007/s00392-015-0839-y. Epub 2015 Mar 19.
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ROSE-AHF and lessons learned.ROSE-AHF及经验教训。
Curr Heart Fail Rep. 2014 Sep;11(3):260-5. doi: 10.1007/s11897-014-0208-6.
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Effects of serelaxin in acute heart failure patients with renal impairment: results from RELAX-AHF.重组松弛素对合并肾功能不全的急性心力衰竭患者的影响：RELAX-AHF研究结果
Clin Res Cardiol. 2016 Sep;105(9):727-37. doi: 10.1007/s00392-016-0979-8. Epub 2016 Mar 26.
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Decongestive therapy and renal function in acute heart failure: time for a new approach?急性心力衰竭中的消肿治疗与肾功能：是时候采用新方法了吗？
Circ Heart Fail. 2014 May;7(3):531-5. doi: 10.1161/CIRCHEARTFAILURE.113.000828.
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Serelaxin in acute heart failure: Most recent update on clinical and preclinical evidence.急性心力衰竭中的松弛素：临床和临床前证据的最新进展。
Cardiovasc Ther. 2017 Feb;35(1):55-63. doi: 10.1111/1755-5922.12231.

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The Early Pharmacological Strategy with Inodilator, bEta-blockers, Mineralocorticoid Receptor Antagonists, Sodium-glucose coTransporter-2 Inhibitors and Angiotensin Receptor-neprylisin Inhibitors in Acute Heart Failure (PENTA-HF).急性心力衰竭中使用血管扩张剂、β受体阻滞剂、盐皮质激素受体拮抗剂、钠-葡萄糖协同转运蛋白2抑制剂和血管紧张素受体脑啡肽酶抑制剂的早期药理学策略（PENTA-HF）
Curr Vasc Pharmacol. 2025;23(3):213-223. doi: 10.2174/0115701611334141241217044516.
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Improvement in Renal Function During the Treatment of Acute Decompensated Heart Failure: Relationship With Markers of Renal Tubular Injury and Prognostic Importance.急性失代偿性心力衰竭治疗期间肾功能的改善：与肾小管损伤标志物的关系及预后意义。
Circ Heart Fail. 2023 Mar;16(3):e009776. doi: 10.1161/CIRCHEARTFAILURE.122.009776. Epub 2023 Jan 26.
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The interstitial compartment as a therapeutic target in heart failure.间质腔室作为心力衰竭的治疗靶点。
Front Cardiovasc Med. 2022 Aug 17;9:933384. doi: 10.3389/fcvm.2022.933384. eCollection 2022.
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Pharmacological interventions for heart failure in people with chronic kidney disease.慢性肾脏病患者心力衰竭的药物干预措施。
Cochrane Database Syst Rev. 2020 Feb 27;2(2):CD012466. doi: 10.1002/14651858.CD012466.pub2.
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Natriuretic Response Is Highly Variable and Associated With 6-Month Survival: Insights From the ROSE-AHF Trial.利钠肽反应具有高度变异性，并与 6 个月生存率相关：来自 ROSE-AHF 试验的观察结果。
JACC Heart Fail. 2019 May;7(5):383-391. doi: 10.1016/j.jchf.2019.01.007.
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Trajectory of Congestion Metrics by Ejection Fraction in Patients With Acute Heart Failure (from the Heart Failure Network).急性心力衰竭患者射血分数与充血指标的轨迹（来自心力衰竭网络）
Am J Cardiol. 2017 Jul 1;120(1):98-105. doi: 10.1016/j.amjcard.2017.03.249. Epub 2017 Apr 12.
7
Implications of Using Different Definitions on Outcomes in Worsening Heart Failure.在心力衰竭恶化中使用不同定义对结局的影响。
Circ Heart Fail. 2016 Aug;9(8). doi: 10.1161/CIRCHEARTFAILURE.116.003048.
8
Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure).射血分数降低或保留的急性心力衰竭患者对小剂量多巴胺或小剂量奈西立肽的不同反应：ROSE AHF试验（急性心力衰竭肾优化策略评估）结果
Circ Heart Fail. 2016 Aug;9(8). doi: 10.1161/CIRCHEARTFAILURE.115.002593.
9
Biomarkers of acute kidney injury and associations with short- and long-term outcomes.急性肾损伤的生物标志物及其与短期和长期预后的关联。
F1000Res. 2016 May 24;5. doi: 10.12688/f1000research.7998.1. eCollection 2016.
10
Timing and Causes of Readmission After Acute Heart Failure Hospitalization-Insights From the Heart Failure Network Trials.急性心力衰竭住院后再入院的时间及原因——来自心力衰竭网络试验的见解
J Card Fail. 2016 Nov;22(11):875-883. doi: 10.1016/j.cardfail.2016.04.014. Epub 2016 Apr 28.

本文引用的文献

1
Effects of nesiritide and predictors of urine output in acute decompensated heart failure: results from ASCEND-HF (acute study of clinical effectiveness of nesiritide and decompensated heart failure).奈西立肽对急性失代偿性心力衰竭的影响及其与尿量的关系：来自 ASCEND-HF（奈西立肽治疗失代偿性心力衰竭的临床疗效评估）的研究结果。
J Am Coll Cardiol. 2013 Sep 24;62(13):1177-83. doi: 10.1016/j.jacc.2013.04.073. Epub 2013 Jun 7.
2
Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association.预测心力衰竭对美国的影响：美国心脏协会的政策声明。
Circ Heart Fail. 2013 May;6(3):606-19. doi: 10.1161/HHF.0b013e318291329a. Epub 2013 Apr 24.
3
Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomes.瑞兰欣在急性心力衰竭（RELAX-AHF）开发项目中对心脏、肾脏和肝脏生物标志物的影响：与结局的相关性。
J Am Coll Cardiol. 2013 Jan 15;61(2):196-206. doi: 10.1016/j.jacc.2012.11.005.
4
Markers of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure.充血标志物、呼吸困难缓解和急性心力衰竭住院患者的临床结局。
Circ Heart Fail. 2013 Mar;6(2):240-5. doi: 10.1161/CIRCHEARTFAILURE.112.969246. Epub 2012 Dec 18.
5
Heart disease and stroke statistics--2013 update: a report from the American Heart Association.《2013年心脏病和中风统计数据更新：美国心脏协会报告》
Circulation. 2013 Jan 1;127(1):e6-e245. doi: 10.1161/CIR.0b013e31828124ad. Epub 2012 Dec 12.
6
Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial.重组人松弛素-2 治疗急性心力衰竭（RELAX-AHF）的随机、安慰剂对照试验。
Lancet. 2013 Jan 5;381(9860):29-39. doi: 10.1016/S0140-6736(12)61855-8. Epub 2012 Nov 7.
7
Ultrafiltration in decompensated heart failure with cardiorenal syndrome.心力衰竭合并心肾综合征失代偿期的超滤治疗。
N Engl J Med. 2012 Dec 13;367(24):2296-304. doi: 10.1056/NEJMoa1210357. Epub 2012 Nov 6.
8
Cardiorenal syndrome type 1: pathophysiological crosstalk leading to combined heart and kidney dysfunction in the setting of acutely decompensated heart failure.1 型心肾综合征：急性失代偿性心力衰竭时导致心脏和肾脏功能障碍合并的病理生理学相互作用。
J Am Coll Cardiol. 2012 Sep 18;60(12):1031-42. doi: 10.1016/j.jacc.2012.01.077. Epub 2012 Jul 25.
9
The worst symptom as defined by patients during heart failure hospitalization: implications for response to therapy.心力衰竭住院期间患者定义的最严重症状：对治疗反应的影响。
J Card Fail. 2012 Jul;18(7):524-33. doi: 10.1016/j.cardfail.2012.04.012. Epub 2012 May 30.
10
Prognostic implications of renal dysfunction in patients hospitalized with heart failure: data from the last decade of clinical investigations.肾功能障碍对心力衰竭住院患者预后的影响：来自过去十年临床研究的数据。
Heart Fail Rev. 2013 Mar;18(2):167-76. doi: 10.1007/s10741-012-9317-z.

Targeting the kidney in acute heart failure: can old drugs provide new benefit? Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE AHF) trial.

作者信息

Chen Horng H, AbouEzzeddine Omar F, Anstrom Kevin J, Givertz Michael M, Bart Bradley A, Felker G Michael, Hernandez Adrian F, Lee Kerry L, Braunwald Eugene, Redfield Margaret M

机构信息

Department of Medicine, Mayo Clinic, Rochester, MN.

出版信息

Circ Heart Fail. 2013 Sep 1;6(5):1087-94. doi: 10.1161/CIRCHEARTFAILURE.113.000347.

DOI:10.1161/CIRCHEARTFAILURE.113.000347
PMID:24046475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3878083/
Abstract
摘要