Jain Anshika, Connolly Erin L
Department of Biological Sciences, University of South Carolina Columbia, SC, USA.
Front Plant Sci. 2013 Sep 6;4:348. doi: 10.3389/fpls.2013.00348.
Iron (Fe) is an essential nutrient for plants and although the mechanisms controlling iron uptake from the soil are relatively well understood, comparatively little is known about subcellular trafficking of iron in plant cells. Mitochondria represent a significant iron sink within cells, as iron is required for the proper functioning of respiratory chain protein complexes. Mitochondria are a site of Fe-S cluster synthesis, and possibly heme synthesis as well. Here we review recent insights into the molecular mechanisms controlling mitochondrial iron transport and homeostasis. We focus on the recent identification of a mitochondrial iron uptake transporter in rice and a possible role for metalloreductases in iron uptake by mitochondria. In addition, we highlight recent advances in mitochondrial iron homeostasis with an emphasis on the roles of frataxin and ferritin in iron trafficking and storage within mitochondria.
铁（Fe）是植物必需的营养元素，虽然控制从土壤中吸收铁的机制已相对为人所知，但关于铁在植物细胞中的亚细胞运输却知之甚少。线粒体是细胞内一个重要的铁库，因为呼吸链蛋白复合物的正常功能需要铁。线粒体是铁硫簇合成的场所，也可能是血红素合成的场所。在这里，我们综述了关于控制线粒体铁运输和稳态的分子机制的最新见解。我们重点关注水稻中线粒体铁摄取转运蛋白的最新鉴定以及金属还原酶在铁被线粒体摄取过程中可能发挥的作用。此外，我们强调线粒体铁稳态的最新进展，重点是酵母铁蛋白和铁蛋白在线粒体内铁运输和储存中的作用。
