Ayukekbong J A, Andersson M E, Vansarla G, Tah F, Nkuo-Akenji T, Lindh M, Bergström T
Department of Infectious Diseases/Section of Clinical Virology, Institute of Biomedicine,University of Gothenburg,Gothenburg,Sweden.
School of Life Science,University of Skövde,Skövde,Sweden.
Epidemiol Infect. 2014 Jul;142(7):1393-402. doi: 10.1017/S095026881300232X. Epub 2013 Sep 19.
We studied the seasonal fluctuation of norovirus and other enteric viruses in Cameroon. Two hundred participants aged between 1 and 69 years were prospectively followed up. Each participant provided monthly faecal samples over a 12-month period. A total of 2484 samples were tested using multiplex real-time PCR assay for the detection of norovirus, rotavirus and enterovirus. The effect of weather variables and risk factors were analysed by Pearson correlation and bivariate analysis. Overall, enterovirus was the most commonly detected virus (21·6% of specimens), followed by norovirus (3·9%) and rotavirus (0·4%). Norovirus and enterovirus were detected throughout the year with a peak of norovirus detection at the beginning of the rainy season and a significant alternation of circulation of norovirus genogroups from one month to the next. Age <5 years and consumption of tap water were risk factors for norovirus infection. Better understanding of factors influencing transmission and seasonality may provide insights into the relationship between physical environment and risk of infection for these viruses.
我们研究了喀麦隆诺如病毒和其他肠道病毒的季节性波动情况。对200名年龄在1至69岁之间的参与者进行了前瞻性随访。每位参与者在12个月的时间里每月提供粪便样本。总共2484份样本通过多重实时聚合酶链反应检测法进行检测，以检测诺如病毒、轮状病毒和肠道病毒。通过Pearson相关性分析和双变量分析来分析天气变量和风险因素的影响。总体而言，肠道病毒是最常检测到的病毒（占样本的21.6%），其次是诺如病毒（3.9%）和轮状病毒（0.4%）。全年均检测到诺如病毒和肠道病毒，诺如病毒检测高峰出现在雨季开始时，且诺如病毒基因组的循环在一个月到下一个月之间有显著变化。年龄小于5岁和饮用自来水是诺如病毒感染的风险因素。更好地了解影响传播和季节性的因素可能有助于深入了解这些病毒的物理环境与感染风险之间的关系。
