Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Institute of Inflammation and Repair, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Rheumatology (Oxford). 2014 Apr;53(4):592-9. doi: 10.1093/rheumatology/ket314. Epub 2013 Sep 18.
Understanding the genetic risk of JIA, a relatively rare chronic disease, is a challenging task, but recent research in this field has shown great advances. This review summarizes the current understanding of the genetic architecture of JIA susceptibility and proposes where this work is heading in the coming years. Insights into how we might progress this relatively understudied field will be provided, highlighting how the field will move towards the ultimate goals of predicting long-term disease outcomes at onset, predicting drug response, and move towards more targeted treatment options for children with JIA.
了解幼年特发性关节炎（JIA）这种相对罕见的慢性疾病的遗传风险是一项具有挑战性的任务，但该领域的最新研究已经取得了重大进展。本综述总结了目前对 JIA 易感性遗传结构的理解，并提出了未来几年这方面工作的发展方向。我们将提供如何推进这一相对研究不足领域的见解，强调该领域将如何朝着预测疾病发病时的长期预后、预测药物反应以及为 JIA 患儿提供更有针对性的治疗方案的最终目标前进。
