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蓝花草和白花紫露草50%乙醇叶提取物对四氧嘧啶诱导的糖尿病大鼠血脂水平的影响。

Effect of 50% hydro-ethanolic leaf extracts of ruellia tuberosa L. And dipteracanthus patulus (jacq.) on lipid profile in alloxan induced diabetic rats.

作者信息

Ananthakrishnan Manikandan, Doss Victor Arokia

机构信息

Department of Biochemistry, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India.

出版信息

Int J Prev Med. 2013 Jul;4(7):744-7.

PMID:24049591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3775212/
Abstract

BACKGROUND

The study was undertaken to investigate the effect of 50% hydro -ethanolic leaf extracts of Ruellia tuberosa L. and Dipteracanthus patulus (Jacq.) on lipid profile in alloxan induced diabetic rats.

METHOD

In lipid profile the parameters studied were serum total cholesterol, phospholipids, triglycerides, HDL-c, LDL-c and VLDL-c level. Extracts were orally administered daily for 30 days at a dosage of 250 and 500 mg/kg bodyweight to alloxan induced diabetic rats.

RESULTS

The levels of phospholipids, triglycerides, LDL-c and VLDL-c were significantly (P < 0.05) reduced. The HDL-c level was found to be increased in the treatment groups. Total cholesterol level was found to be significantly (P < 0.05) decreased at 500 mg/kg bodyweight of both the plant extracts treated groups.

CONCLUSION

The results further suggests that the effect of plant extract treated groups was found to be lower in reducing the lipid levels in serum when compared to the drug (Glibenclamide 600 μg/kg body weight) treated group.

摘要

背景

本研究旨在探讨蓝花草和尖蕊花50%水乙醇叶提取物对四氧嘧啶诱导的糖尿病大鼠血脂水平的影响。

方法

在血脂检测中，所研究的参数包括血清总胆固醇、磷脂、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇水平。将提取物以250和500mg/kg体重的剂量每日口服给药30天，给予四氧嘧啶诱导的糖尿病大鼠。

结果

磷脂、甘油三酯、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇水平显著降低（P<0.05）。发现治疗组的高密度脂蛋白胆固醇水平有所升高。在两个植物提取物治疗组中，体重500mg/kg时总胆固醇水平显著降低（P<0.05）。

结论

结果进一步表明，与药物（格列本脲600μg/kg体重）治疗组相比，植物提取物治疗组在降低血清脂质水平方面的效果较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7b/3775212/c685a8fe6560/IJPVM-4-744-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7b/3775212/81b763257a77/IJPVM-4-744-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7b/3775212/c685a8fe6560/IJPVM-4-744-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7b/3775212/81b763257a77/IJPVM-4-744-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7b/3775212/c685a8fe6560/IJPVM-4-744-g002.jpg

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本文引用的文献

1
Preliminary studies on acute and subacute toxicity of an antidiabetic herbal preparation, Dianex.一种抗糖尿病草药制剂Dianex的急性和亚急性毒性初步研究。
Indian J Exp Biol. 2003 Apr;41(4):316-20.
2
Diabetes & coronary artery disease.糖尿病与冠状动脉疾病。
Indian J Med Res. 2002 Nov;116:163-76.
3
Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats.匙羹藤根在四氧嘧啶诱导的糖尿病大鼠中的降血糖及其他相关作用。
罗伊氏乳杆菌对高脂饮食和链脲佐菌素诱导的2型糖尿病大鼠主动脉内皮损伤相关因子的影响。
Food Sci Nutr. 2019 Oct 9;7(11):3742-3750. doi: 10.1002/fsn3.1233. eCollection 2019 Nov.
4
Ameliorative effect of L. on hyperglycemia in type 2 diabetes mellitus and glucose uptake in mouse C2C12 myoblasts.L. 对 2 型糖尿病高血糖的改善作用及对小鼠 C2C12 成肌细胞葡萄糖摄取的影响。
Food Sci Nutr. 2018 Oct 10;6(8):2414-2422. doi: 10.1002/fsn3.840. eCollection 2018 Nov.
J Ethnopharmacol. 2000 Apr;70(1):9-15. doi: 10.1016/s0378-8741(99)00136-1.
4
Effect of D-400, a herbal formulation, on blood sugar of normal and alloxan-induced diabetic rats.草药制剂D - 400对正常及四氧嘧啶诱导的糖尿病大鼠血糖的影响。
Indian J Physiol Pharmacol. 1995 Apr;39(2):95-100.
5
Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum.诺卡氏菌属胆固醇氧化酶的制备、性质及其在血清总胆固醇酶法测定中的应用。
Clin Chem. 1973 Dec;19(12):1350-6.
6
New colorimetric method for the quantitative estimation of phospholipids without acid digestion.无需酸消解的磷脂定量新比色法。
J Lipid Res. 1973 Nov;14(6):695-7.
7
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.无需使用制备性超速离心机来估算血浆中低密度脂蛋白胆固醇的浓度。
Clin Chem. 1972 Jun;18(6):499-502.
8
Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity.
J Lipid Res. 1989 Dec;30(12):1827-34.
9
Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus.
J Ethnopharmacol. 1990 Oct;30(3):281-94. doi: 10.1016/0378-8741(90)90107-5.
10
HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study.高密度脂蛋白胆固醇及其他脂质与冠心病。合作脂蛋白表型研究。
Circulation. 1977 May;55(5):767-72. doi: 10.1161/01.cir.55.5.767.