蓝花草和白花紫露草50%乙醇叶提取物对四氧嘧啶诱导的糖尿病大鼠血脂水平的影响。
Effect of 50% hydro-ethanolic leaf extracts of ruellia tuberosa L. And dipteracanthus patulus (jacq.) on lipid profile in alloxan induced diabetic rats.
作者信息
Ananthakrishnan Manikandan, Doss Victor Arokia
机构信息
Department of Biochemistry, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India.
出版信息
Int J Prev Med. 2013 Jul;4(7):744-7.
BACKGROUND
The study was undertaken to investigate the effect of 50% hydro -ethanolic leaf extracts of Ruellia tuberosa L. and Dipteracanthus patulus (Jacq.) on lipid profile in alloxan induced diabetic rats.
METHOD
In lipid profile the parameters studied were serum total cholesterol, phospholipids, triglycerides, HDL-c, LDL-c and VLDL-c level. Extracts were orally administered daily for 30 days at a dosage of 250 and 500 mg/kg bodyweight to alloxan induced diabetic rats.
RESULTS
The levels of phospholipids, triglycerides, LDL-c and VLDL-c were significantly (P < 0.05) reduced. The HDL-c level was found to be increased in the treatment groups. Total cholesterol level was found to be significantly (P < 0.05) decreased at 500 mg/kg bodyweight of both the plant extracts treated groups.
CONCLUSION
The results further suggests that the effect of plant extract treated groups was found to be lower in reducing the lipid levels in serum when compared to the drug (Glibenclamide 600 μg/kg body weight) treated group.
背景
本研究旨在探讨蓝花草和尖蕊花50%水乙醇叶提取物对四氧嘧啶诱导的糖尿病大鼠血脂水平的影响。
方法
在血脂检测中，所研究的参数包括血清总胆固醇、磷脂、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇水平。将提取物以250和500mg/kg体重的剂量每日口服给药30天，给予四氧嘧啶诱导的糖尿病大鼠。
结果
磷脂、甘油三酯、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇水平显著降低（P<0.05）。发现治疗组的高密度脂蛋白胆固醇水平有所升高。在两个植物提取物治疗组中，体重500mg/kg时总胆固醇水平显著降低（P<0.05）。
结论
结果进一步表明，与药物（格列本脲600μg/kg体重）治疗组相比，植物提取物治疗组在降低血清脂质水平方面的效果较低。
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