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Anti-inflammatory and analgesic activities of Melanthera scandens.黑腺金钮扣的抗炎和镇痛活性。
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Asian Pac J Trop Biomed. 2012 Jan;2(1):16-20. doi: 10.1016/S2221-1691(11)60182-2.
3
Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats.用拉马克八角枫叶的醇提物治疗链脲佐菌素-烟酰胺诱导的 2 型糖尿病大鼠的抗糖尿病活性。
Asian Pac J Trop Med. 2011 Nov;4(11):904-9. doi: 10.1016/S1995-7645(11)60216-2.
4
Antidiabetic activity of methanolic bark extract of Albizia odoratissima Benth. in alloxan induced diabetic albino mice.阿勃勒树皮甲醇提取物对四氧嘧啶致糖尿病白化病小鼠的降血糖活性。
Asian Pac J Trop Med. 2011 Nov;4(11):900-3. doi: 10.1016/S1995-7645(11)60215-0.
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Antidiabetic, antihyperlipidemic and antioxidant potential of methanol extract of Tectona grandis flowers in streptozotocin induced diabetic rats.在链脲佐菌素诱导的糖尿病大鼠中，柚花木甲醇提取物的降血糖、降血脂和抗氧化潜力。
Asian Pac J Trop Med. 2011 Aug;4(8):624-31. doi: 10.1016/S1995-7645(11)60160-0.
6
Antidiabetic, hypolipidemic and histopathological analysis of Dillenia indica (L.) leaves extract on alloxan induced diabetic rats.匙羹藤（Dillenia indica（L.））叶提取物对四氧嘧啶诱导糖尿病大鼠的降血糖、降血脂作用及组织病理学分析。
Asian Pac J Trop Med. 2011 May;4(5):347-52. doi: 10.1016/S1995-7645(11)60101-6. Epub 2011 Jun 22.
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Evaluation of antidiabetic and related actions of some Indian medicinal plants in diabetic rats.评价几种印度药用植物在糖尿病大鼠中的抗糖尿病及相关作用。
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Evaluation of Antioxidant Potential of Melanthera scandens.黑腺金钮扣抗氧化潜力的评估
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An ethnopharmacological survey and in vitro confirmation of ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana.加纳博索姆特维-阿特维马-夸诺沃马地区用于伤口愈合的药用植物的民族药理学调查及民族药理学应用的体外验证
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Antiplasmodial activity of root extract and fractions of Croton zambesicus.赞比亚巴豆根提取物及其馏分的抗疟活性。
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黑腺金纽扣乙醇叶提取物及其馏分的抗糖尿病和降血脂活性

Antidiabetic and hypolipidemic activities of ethanolic leaf extract and fractions of Melanthera scandens.

作者信息

Akpan Enomfon J, Okokon Jude E, Offong Emem

机构信息

Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria.

出版信息

Asian Pac J Trop Biomed. 2012 Jul;2(7):523-7. doi: 10.1016/S2221-1691(12)60089-6.

DOI:10.1016/S2221-1691(12)60089-6
PMID:23569963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3609341/
Abstract

OBJECTIVE

To evaluate the antidiabetic and hypolipidemic activities of ethanolic leaf extract and fraction of Melanthera scandens (M. scandens) in alloxan-induced diabetic rats.

METHODS

M. scandens leaf extract/fractions (37-111 mg/kg) were administered to alloxan-induced diabetic rats for 14 days and blood glucose levels (BGL) of the diabetic rats were monitored at intervals of 7 hours for acute study and 14 days for prolonged study. Lipid profiles of the treated diabetic rats were determined after the period of treatment.

RESULTS

Treatment of alloxan-induced diabetic rats with the extract/fractions caused a significant (P<0.001) reduction in fasting bloodglucose levels (BGL) of the diabetic rats both in acute study and prolonged treatment (2 weeks). The activities of the extract and fractions were more than that of the reference drug, glibenclamide. The extract/fractions exerted a significant reduction in the levels of serum total cholesterol, triglycerides, LDL and VLDL of extract with increases in HDL levels of the diabetic rats.

CONCLUSIONS

These results suggest that the leaf extract/fractions of M. scandens possesses antidiabetic effect on alloxan induced diabetic rats and this justifies its use in ethno medicine and can be exploited in the management of diabetes.

摘要

目的

评估黑腺蝴蝶草乙醇叶提取物及其馏分对四氧嘧啶诱导的糖尿病大鼠的抗糖尿病和降血脂活性。

方法

将黑腺蝴蝶草叶提取物/馏分（37 - 111毫克/千克）给予四氧嘧啶诱导的糖尿病大鼠，为期14天。在急性研究中，每隔7小时监测糖尿病大鼠的血糖水平（BGL）；在长期研究中，监测14天。治疗期结束后，测定治疗的糖尿病大鼠的血脂谱。

结果

在急性研究和长期治疗（2周）中，用提取物/馏分治疗四氧嘧啶诱导的糖尿病大鼠均导致糖尿病大鼠空腹血糖水平（BGL）显著降低（P<0.001）。提取物及其馏分的活性高于参比药物格列本脲。提取物/馏分使糖尿病大鼠血清总胆固醇、甘油三酯、低密度脂蛋白和极低密度脂蛋白水平显著降低，同时高密度脂蛋白水平升高。

结论

这些结果表明，黑腺蝴蝶草叶提取物/馏分对四氧嘧啶诱导的糖尿病大鼠具有抗糖尿病作用，这证明了其在民族医学中的应用合理性，并且可用于糖尿病的管理。