亚麻籽固定油对炎症不同阶段的作用。
Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation.
作者信息
Kaithwas Gaurav, Majumdar Dipak K
机构信息
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Vidyavihar, Lucknow, Uttar Pradesh 226 025, India ; Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, Allahabad Agricultural Institute-Deemed University, Allahabad, Uttar Pradesh 211 007, India.
出版信息
ISRN Inflamm. 2013 Feb 17;2013:735158. doi: 10.1155/2013/735158. eCollection 2013.
Abstract
The present investigation summarizes the effect of Linum usitatissimum fixed oil against different phases of acute inflammatory reaction, namely, protein exudation, peritoneal capillary permeability, and leukocyte migration. The fixed oil exhibited dose-dependent inhibition of protein exudation vascular permeability, comparable to standard aspirin. The oil also inhibited the leukocyte migration in pleural exudates in a dose-dependent manner. Production of less vasodilatory (PGE3) and chemotactic (LTB5) eicosanoids through EPA (derived from linolenic acid) metabolism could account for the above observations.
摘要
本研究总结了亚麻籽固定油对急性炎症反应不同阶段的影响，即蛋白质渗出、腹膜毛细血管通透性和白细胞迁移。该固定油对蛋白质渗出和血管通透性表现出剂量依赖性抑制作用，与标准阿司匹林相当。该油还以剂量依赖性方式抑制胸膜渗出液中的白细胞迁移。通过EPA（源自亚麻酸）代谢产生较少的血管舒张性（PGE3）和趋化性（LTB5）类二十烷酸可能解释了上述观察结果。
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本文引用的文献
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