Department of Applied Plant Sciences, SB&BT, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Vidya Vihar, Lucknow, 226 025, Uttar Pradesh, India.
Inflammopharmacology. 2015 Feb;23(1):65-70. doi: 10.1007/s10787-014-0223-y. Epub 2014 Dec 10.
The present work investigates the anti-inflammatory, analgesic and antipyretic activity of methanolic extract of mulberry leaves of variety S-1, S-13 and S-146. The S-146 extract was further evaluated for its efficacy against adjuvant arthritis in albino rats followed by inhibitory potential for COX 1, COX 2 and 5 LOX. The HPLC analysis enumerated the presence of morin, reversterol, scopoletin and 7-hydroxy coumarin as the major constituents. The anti-inflammatory, antipyretic and analgesic activity observed in the present experiment could be accredited to the dual inhibition in the AA pathway. The inhibition of COX and LOX enzymes could be imparted to the presence of resveraterol, morin, scopoletin and 7-hydroxy coumarin.
本研究调查了桑品种 S-1、S-13 和 S-146 的甲醇提取物的抗炎、镇痛和解热活性。S-146 提取物进一步在白化大鼠中评估其对佐剂性关节炎的疗效，随后评估其对 COX 1、COX 2 和 5-LOX 的抑制潜力。HPLC 分析表明，主要成分有桑色素、白藜芦醇、瑞香素和 7-羟基香豆素。本实验中观察到的抗炎、解热和镇痛活性可归因于 AA 途径的双重抑制。COX 和 LOX 酶的抑制作用可能归因于白藜芦醇、桑色素、瑞香素和 7-羟基香豆素的存在。
