Kaithwas Gaurav, Mukherjee Alok, Chaurasia A K, Majumdar Dipak K
Department of Pharmaceutical Sciences, Faculty of Health & Medical Sciences, Allahabad Agricultural Institute-Deemed University, Allahabad 211 007, India.
Indian J Exp Biol. 2011 Dec;49(12):932-8.
The fixed oil of L. usitatissimum (flaxseed/linseed) inhibited PGE2-, leukotriene-, histamine- and bradykinin-induced inflammation. The oil also inhibited arachidonic acid-induced inflammation, suggesting its capacity to inhibit both cyclooxygenase and lipoxygenase pathways of arachidonate metabolism. In tail immersion model, the oil raised the pain threshold to a lesser extent than morphine but showed excellent peripherally acting, analgesic activity comparable to aspirin, against acetic acid-induced writhing in mouse. In typhoid paratyphoid A/B vaccine-induced pyrexia, the oil showed antipyretic activity comparable to aspirin. The oil contains 57.38% alpha-linolenic acid. Dual inhibition of arachidonic acid metabolism, antihistaminic and antibradykinin activities of the oil could account for the biological activity and the active principle could be alpha-linolenic acid an omega-3 (18:3, n-3) fatty acid.
亚麻（亚麻籽/胡麻籽）的不挥发油可抑制前列腺素E2、白三烯、组胺和缓激肽诱导的炎症。该油还可抑制花生四烯酸诱导的炎症，表明其具有抑制花生四烯酸代谢中环氧化酶和脂氧合酶途径的能力。在尾部浸入模型中，该油提高疼痛阈值的程度低于吗啡，但对小鼠乙酸诱导的扭体反应显示出与阿司匹林相当的出色外周镇痛活性。在伤寒副伤寒A/B疫苗诱导的发热中，该油显示出与阿司匹林相当的解热活性。该油含有57.38%的α-亚麻酸。该油对花生四烯酸代谢的双重抑制、抗组胺和抗缓激肽活性可解释其生物活性，其活性成分可能是α-亚麻酸，一种ω-3（18:3，n-3）脂肪酸。
