Kebria Mehdi M, Belinson Jerome, Kim Robert, Mekhail Tarek M
Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Gynecol Oncol. 2006 May;101(2):353-5. doi: 10.1016/j.ygyno.2005.12.024. Epub 2006 Jan 27.
Malignant acanthosis nigricans is a mucocutaneous eruption associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. The sign of Leser-Tre'lat is the presence of multiple seborrheic keratoses and scattered skin tags caused by a malignancy. We are reporting the first case of ovarian cancer in association with three coexisting cutaneous paraneoplastic dermatosis.
A 52-year-old female presented with skin manifestation consistent with MAN, TP and the sign of Leser-Tre'lat. Patient underwent extensive work up and was discovered to have stage I, high grade adenocarcinoma of the ovary. Skin manifestations gradually recovered after initiation of chemotherapy.
The presence of acanthosis nigricans in conjunction with tripe palms and the sign of Leser-Tre'lat are highly suggestive of an internal malignancy and necessitate an extensive investigation in order to discover the underlying malignancy.
恶性黑棘皮病是一种与内脏恶性肿瘤相关的皮肤黏膜疹。掌跖角化病是指手掌出现特征性的天鹅绒样增厚，正常皮肤纹路加深。Leser-Tre'lat征是指由恶性肿瘤引起的多发性脂溢性角化病和散在的皮肤软纤维瘤。我们报告首例卵巢癌合并三种并存的皮肤副肿瘤性皮肤病。
一名52岁女性出现与恶性黑棘皮病、掌跖角化病和Leser-Tre'lat征相符的皮肤表现。患者接受了全面检查，被发现患有Ⅰ期高级别卵巢腺癌。化疗开始后，皮肤表现逐渐恢复。
黑棘皮病合并掌跖角化病和Leser-Tre'lat征高度提示存在内脏恶性肿瘤，需要进行全面检查以发现潜在的恶性肿瘤。
