Selnes O A, Miller E, McArthur J, Gordon B, Muñoz A, Sheridan K, Fox R, Saah A J
Johns Hopkins Medical Institutions, Baltimore, MD.
Neurology. 1990 Feb;40(2):204-8. doi: 10.1212/wnl.40.2.204.
Cross-sectional studies have not adequately resolved the question of whether subjects infected with HIV-1 may suffer cognitive decline during the early, asymptomatic stages of the infection. We studied longitudinally 238 asymptomatic healthy HIV-1-infected homosexual/bisexual men (CDC groups 2 and 3) and 170 uninfected controls in the Multicenter AIDS Cohort Study with neuropsychological testing at semiannual intervals. A comparison of change in scores between visits 1 and 4 as well as a multivariate autoregressive analysis revealed no evidence of decline in test performance over time in the HIV-1-infected group compared with the seronegative controls. These findings suggest that a gradual cognitive decline does not occur during the early, asymptomatic stages of HIV infection.
横断面研究尚未充分解决感染HIV-1的个体在感染早期无症状阶段是否会出现认知功能衰退这一问题。在多中心艾滋病队列研究中，我们对238名无症状的健康HIV-1感染同性恋/双性恋男性（疾病控制与预防中心第2和3组）以及170名未感染对照者进行了纵向研究，每隔半年进行一次神经心理学测试。对第1次和第4次访视之间的分数变化进行比较以及多变量自回归分析显示，与血清学阴性对照相比，HIV-1感染组的测试表现没有随时间下降的迹象。这些发现表明，在HIV感染的早期无症状阶段不会出现渐进性认知衰退。
