Yusuf Imran H, Sahare Prashant, Hildebrand G Darius
Royal Berkshire Hospital NHS Foundation Trust, London Road, Reading, United Kingdom.
J AAPOS. 2013 Oct;17(5):521-3. doi: 10.1016/j.jaapos.2013.05.011. Epub 2013 Sep 17.
Children treated for toxoplasma retinochoroiditis may experience a range of severe adverse drug responses. Drug reaction with eosinophilia and systemic symptoms syndrome is a life-threatening idiosyncratic drug reaction with a 10% mortality. We present a case of drug reaction with eosinophilia and systemic symptoms syndrome in a child on standard combination treatment with oral sulfadiazine, pyrimethamine, folinic acid, and steroids for toxoplasma retinochoroiditis. Early clinical recognition and appropriate treatment led to a complete recovery and no longterm sequelae. The parents of children during sulfadiazine treatment should be counseled on the potential significance of nonspecific illness.
接受弓形虫视网膜脉络膜炎治疗的儿童可能会出现一系列严重的药物不良反应。药物性嗜酸性粒细胞增多和全身症状综合征是一种危及生命的特异质性药物反应，死亡率为10%。我们报告一例接受弓形虫视网膜脉络膜炎标准联合治疗（口服磺胺嘧啶、乙胺嘧啶、亚叶酸和类固醇）的儿童发生药物性嗜酸性粒细胞增多和全身症状综合征的病例。早期临床识别和适当治疗导致完全康复且无长期后遗症。在磺胺嘧啶治疗期间，应向儿童家长说明非特异性疾病的潜在重要性。
