Department of Rheumatology, Concord Hospital, Sydney; The University of Sydney, Australia.
Indian J Med Res. 2013;138(2):185-93.
The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility and negative impact on quality of life. OA pathogenesis relates to both excessive joint loading and altered biomechanical patterns together with hormonal and cytokine dysregulation. Obesity is associated with the incidence and progression of OA of both weight-bearing and non weight-bearing joints, to rate of joint replacements as well as operative complications. Weight loss in OA can impart clinically significant improvements in pain and delay progression of joint structural damage. Further work is required to determine the relative contributions of mechanical and metabolic factors in the pathogenesis of OA.
肥胖症对肌肉骨骼系统的最显著影响与骨关节炎（OA）有关，OA 是一种使人丧失能力的退行性关节疾病，其特征是疼痛、活动能力下降和生活质量受到负面影响。OA 的发病机制与关节负荷过重和生物力学模式改变以及激素和细胞因子失调都有关系。肥胖症与承重和非承重关节 OA 的发病率和进展、关节置换率以及手术并发症都有关联。OA 患者减肥可显著改善疼痛，并延缓关节结构损伤的进展。还需要进一步研究来确定机械和代谢因素在 OA 发病机制中的相对作用。
