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本文引用的文献

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Neurosurg Pract. 2023 Jun 15;4(3):e00044. doi: 10.1227/neuprac.0000000000000044. eCollection 2023 Sep.
2
Frailty Screening Using the Risk Analysis Index: A User Guide.使用风险分析指数进行衰弱筛查:用户指南
Jt Comm J Qual Patient Saf. 2025 Mar;51(3):178-191. doi: 10.1016/j.jcjq.2024.12.005. Epub 2024 Dec 19.
3
Effectiveness of Risk Analysis Index Frailty Scores as a Predictor of Adverse Outcomes in Lower Extremity Reconstruction.风险分析指数衰弱评分作为下肢重建不良结局预测指标的有效性
J Reconstr Microsurg. 2025 Jun;41(5):376-382. doi: 10.1055/a-2383-6916. Epub 2024 Aug 12.
4
Risk analysis index predicts mortality and non-home discharge following posterior lumbar interbody fusion: a nationwide inpatient sample analysis of 429,380 patients (2019-2020).风险分析指数预测后路腰椎椎体间融合术后的死亡率和非出院回家:全国住院患者样本分析 429380 例(2019-2020 年)。
Eur Spine J. 2024 Sep;33(9):3484-3491. doi: 10.1007/s00586-024-08373-9. Epub 2024 Jun 20.
5
Risk Analysis Index and 30-Day Mortality after Brain Tumor Resection: A Multicenter Frailty Analysis of 31,776 Patients from 2012 to 2020.脑肿瘤切除术后的风险分析指数与30天死亡率:对2012年至2020年31776例患者的多中心脆弱性分析
J Neurol Surg B Skull Base. 2023 Feb 13;85(2):168-171. doi: 10.1055/a-2015-1162. eCollection 2024 Apr.
6
Update on the Obesity Epidemic: After the Sudden Rise, Is the Upward Trajectory Beginning to Flatten?肥胖症的最新动态:飙升之后,上扬轨迹是否开始趋平?
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7
A comprehensive analysis of the triad of frailty, aging, and obesity in spine surgery: the risk analysis index predicted 30-day mortality with superior discrimination.对脆弱、衰老和肥胖三联征在脊柱手术中的综合分析:风险分析指数具有优越的鉴别力预测 30 天死亡率。
Spine J. 2023 Dec;23(12):1778-1789. doi: 10.1016/j.spinee.2023.08.008. Epub 2023 Aug 23.
8
Go Big or Go Home: Obesity and Total Joint Arthroplasty.去大或回家:肥胖与全关节置换术。
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9
The Impact of Metabolic Syndrome and Obesity on Perioperative Total Joint Arthroplasty Outcomes: The Obesity Paradox and Risk Assessment in Total Joint Arthroplasty.代谢综合征和肥胖对围手术期全关节置换术结果的影响:全关节置换术中的肥胖悖论与风险评估
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Comparison of the Risk Analysis Index and the modified 5-factor frailty index in predicting 30-day morbidity and mortality after spine surgery.比较风险分析指数和改良的 5 因素衰弱指数预测脊柱手术后 30 天发病率和死亡率。
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风险分析指标作为择期全关节置换术老年肥胖患者30天死亡率的预测指标。

The risk analysis index as a predictor of 30-day mortality for elderly obese patients undergoing elective total joint arthroplasty.

作者信息

Gupta Nithin, Sasaki Jared, Koltenyuk Victor, Park Amber, Chmait Hikmat R, Perugini Anthony, Campbell Andrew B

机构信息

Department of Orthopaedic Surgery, Jefferson Health NJ, Cherry Hill, NJ, USA.

School of Medicine, New York Medical College, USA.

出版信息

J Orthop. 2025 May 5;65:178-184. doi: 10.1016/j.jor.2025.05.009. eCollection 2025 Jul.

DOI:10.1016/j.jor.2025.05.009
PMID:40487330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12142224/
Abstract

INTRODUCTION

The older population of the United States of America is continuing to increase, leading to rising rates of degenerative joint disease. Combined with the high prevalence of obesity in the US, orthopaedic surgeons are performing record numbers of elective total joint arthroplasty (TJA) procedures in higher risk patients. As age and obesity are risk factors for mortality following TJA, preoperative risk stratification tools such as frailty may be used to optimize surgical candidate selection to mitigate adverse outcomes.

METHODS

The American College of Surgeons National Surgical Quality Improvement Program database was queried for patients ≥65 years of age with a BMI of ≥30 kg/m who underwent elective primary total knee or total hip arthroplasty for degenerative joint disease. Frailty was measured using the 5-item Modified Frailty Index (mFI-5) and the Risk Analysis Index (RAI). Multivariate regression was performed to evaluate predictive value of frailty and discriminatory accuracy was quantified using receiver operating characteristic (ROC) analysis.

RESULTS

There were 169,065 patients who met the inclusion criteria from 2015 to 2019. The median age was 71 years, 60.8 % were women and 72.6 % were White. Increasing frailty predicted greater mortality as measured by the RAI and mFI-5. Further, the RAI had superior discrimination compared to the mFI-5 when quantified using ROC analysis.

DISCUSSION

Frailty as measured by the RAI has superior clinical applicability, predictive value and discrimination for identifying patients at risk of mortality following TJA in an older obese population. Given this, orthopaedic surgeons may use the RAI as a tool for optimizing candidate selection and identifying high risk patients preoperatively.

摘要

引言

美利坚合众国的老年人口持续增加,导致退行性关节疾病的发病率不断上升。再加上美国肥胖症的高患病率,骨科医生正在为风险较高的患者进行创纪录数量的择期全关节置换术(TJA)。由于年龄和肥胖是TJA术后死亡的风险因素,术前风险分层工具(如虚弱程度)可用于优化手术候选人的选择,以减轻不良后果。

方法

查询美国外科医师学会国家外科质量改进计划数据库,以获取年龄≥65岁、体重指数≥30kg/m²且因退行性关节疾病接受择期初次全膝关节或全髋关节置换术的患者。使用5项改良虚弱指数(mFI-5)和风险分析指数(RAI)来衡量虚弱程度。进行多变量回归以评估虚弱程度的预测价值,并使用受试者工作特征(ROC)分析对鉴别准确性进行量化。

结果

2015年至2019年期间有169,065名患者符合纳入标准。中位年龄为71岁,60.8%为女性,72.6%为白人。RAI和mFI-5测量结果显示,虚弱程度增加预示着更高的死亡率。此外,使用ROC分析进行量化时,RAI的鉴别能力优于mFI-5。

讨论

RAI所衡量的虚弱程度在识别老年肥胖人群TJA术后死亡风险患者方面具有卓越的临床适用性、预测价值和鉴别能力。鉴于此,骨科医生可将RAI作为优化候选人选择和术前识别高危患者的工具。