Gupta Nithin, Sasaki Jared, Koltenyuk Victor, Park Amber, Chmait Hikmat R, Perugini Anthony, Campbell Andrew B
Department of Orthopaedic Surgery, Jefferson Health NJ, Cherry Hill, NJ, USA.
School of Medicine, New York Medical College, USA.
J Orthop. 2025 May 5;65:178-184. doi: 10.1016/j.jor.2025.05.009. eCollection 2025 Jul.
The older population of the United States of America is continuing to increase, leading to rising rates of degenerative joint disease. Combined with the high prevalence of obesity in the US, orthopaedic surgeons are performing record numbers of elective total joint arthroplasty (TJA) procedures in higher risk patients. As age and obesity are risk factors for mortality following TJA, preoperative risk stratification tools such as frailty may be used to optimize surgical candidate selection to mitigate adverse outcomes.
The American College of Surgeons National Surgical Quality Improvement Program database was queried for patients ≥65 years of age with a BMI of ≥30 kg/m who underwent elective primary total knee or total hip arthroplasty for degenerative joint disease. Frailty was measured using the 5-item Modified Frailty Index (mFI-5) and the Risk Analysis Index (RAI). Multivariate regression was performed to evaluate predictive value of frailty and discriminatory accuracy was quantified using receiver operating characteristic (ROC) analysis.
There were 169,065 patients who met the inclusion criteria from 2015 to 2019. The median age was 71 years, 60.8 % were women and 72.6 % were White. Increasing frailty predicted greater mortality as measured by the RAI and mFI-5. Further, the RAI had superior discrimination compared to the mFI-5 when quantified using ROC analysis.
Frailty as measured by the RAI has superior clinical applicability, predictive value and discrimination for identifying patients at risk of mortality following TJA in an older obese population. Given this, orthopaedic surgeons may use the RAI as a tool for optimizing candidate selection and identifying high risk patients preoperatively.
美利坚合众国的老年人口持续增加,导致退行性关节疾病的发病率不断上升。再加上美国肥胖症的高患病率,骨科医生正在为风险较高的患者进行创纪录数量的择期全关节置换术(TJA)。由于年龄和肥胖是TJA术后死亡的风险因素,术前风险分层工具(如虚弱程度)可用于优化手术候选人的选择,以减轻不良后果。
查询美国外科医师学会国家外科质量改进计划数据库,以获取年龄≥65岁、体重指数≥30kg/m²且因退行性关节疾病接受择期初次全膝关节或全髋关节置换术的患者。使用5项改良虚弱指数(mFI-5)和风险分析指数(RAI)来衡量虚弱程度。进行多变量回归以评估虚弱程度的预测价值,并使用受试者工作特征(ROC)分析对鉴别准确性进行量化。
2015年至2019年期间有169,065名患者符合纳入标准。中位年龄为71岁,60.8%为女性,72.6%为白人。RAI和mFI-5测量结果显示,虚弱程度增加预示着更高的死亡率。此外,使用ROC分析进行量化时,RAI的鉴别能力优于mFI-5。
RAI所衡量的虚弱程度在识别老年肥胖人群TJA术后死亡风险患者方面具有卓越的临床适用性、预测价值和鉴别能力。鉴于此,骨科医生可将RAI作为优化候选人选择和术前识别高危患者的工具。