Denham M J
Northwick Park Hospital, Harrow, Middlesex, UK.
Br Med Bull. 1990 Jan;46(1):53-62. doi: 10.1093/oxfordjournals.bmb.a072394.
The elderly have benefitted considerably from the vast increase in the range of drugs available for prescription. However it is now well recognized that the incidence in adverse drug reactions increases with age. This is mainly due to altered pharmacodynamics and pharmacokinetics as well as multiple prescribing and the effect of illness rather than the effect of age per se. Since adverse drug reactions are such a potent cause of illness, it is sensible for doctors to follow simple rules when prescribing for the elderly.
老年人从可用于处方的药物种类大幅增加中受益匪浅。然而,现在人们已经充分认识到药物不良反应的发生率会随着年龄的增长而增加。这主要是由于药效学和药代动力学的改变、多种药物的开具以及疾病的影响,而不是年龄本身的影响。由于药物不良反应是导致疾病的一个重要原因,医生在为老年人开处方时遵循一些简单的规则是明智的。