Nakano S, Ogawa N, Kawazu Y, Osato E
J Clin Pharmacol. 1978 Feb-Mar;18(2-3):125-30. doi: 10.1002/j.1552-4604.1978.tb02432.x.
The present study was carried out to clarify the effects of an antianxiety drug and of personality characteristics on a psychomotor performance test. Forty-eight healthy women college students were chosen from 64 volunteers as having either high or low levels of trait anxiety, neuroticism, or extroversion. Subjects with high trait anxiety and/or neuroticism tended to show a decrease in both speed and accuracy of the mirror drawing test (MDT) in the initial nondrug trials. Bromazepam, 5 mg, a benzodiazepine derivative, decreased this decrement in highly anxious subjects but worsened the speed in less anxious subjects. The personality traits of subjects, as well as the degree to which a performance test will induce stress, must be considered when evaluating the effects of antianxiety drugs on the performance of normal volunteers. The clinical anxiety-reducing efficacy of drugs may be predicted by using the MDT in subjects with high levels of anxiety and/or neuroticism.
本研究旨在阐明一种抗焦虑药物和人格特征对一项心理运动性能测试的影响。从64名志愿者中挑选出48名健康女大学生，她们具有高或低水平的特质焦虑、神经质或外向性。在最初的非药物试验中，具有高特质焦虑和/或神经质的受试者在镜像绘图测试（MDT）中的速度和准确性往往会下降。5毫克溴马西泮，一种苯二氮䓬衍生物，减少了高度焦虑受试者的这种下降，但降低了低焦虑受试者的速度。在评估抗焦虑药物对正常志愿者性能的影响时，必须考虑受试者的人格特质以及性能测试诱发压力的程度。通过对高焦虑和/或神经质受试者使用MDT，可以预测药物的临床抗焦虑疗效。
