Lønbro Simon
Dept. of Public Health, Section for Sports Science, Aarhus University, Denmark; Dept. of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.
Radiother Oncol. 2014 Jan;110(1):71-80. doi: 10.1016/j.radonc.2013.07.008. Epub 2013 Sep 20.
Loss of lean body mass is a common problem in many post-treatment cancer patients and may negatively affect physical capacity in terms of maximal muscle strength and functional performance. The purpose of this study was to systematically review the scientific evidence on the effect of progressive resistance training on lean body mass in post-treatment cancer patients. A comprehensive literature search was conducted and ultimately 12 studies were included. Methodological quality of the included studies was evaluated using the PEDro scale and the effect of progressive resistance training was reported as the range of mean changes among RCTs and non-RCTs. Six RCTs and six non-RCTs were included in the study. In the RCTs the change in lean body mass in the progressive resistance training groups relative to control groups ranged from -0.4% to 3.9%, and in four of six trials the training effect was significantly larger than the change in the control groups. In the six non-RCTs, the mean change in lean body mass over time ranged from -0.01 to 11.8% which was significant in two of the trials. The included studies reported no or very limited adverse events following progressive resistance training. Based on 12 heterogenic studies there is moderate evidence supporting a positive effect of progressive resistance training on lean body mass in post-treatment cancer patients.
瘦体重的减少是许多癌症治疗后患者的常见问题，可能会对最大肌肉力量和功能表现方面的身体能力产生负面影响。本研究的目的是系统回顾关于渐进性抗阻训练对癌症治疗后患者瘦体重影响的科学证据。进行了全面的文献检索，最终纳入了12项研究。使用PEDro量表评估纳入研究的方法学质量，并将渐进性抗阻训练的效果报告为随机对照试验（RCT）和非随机对照试验中平均变化的范围。该研究纳入了6项RCT和6项非RCT。在RCT中，渐进性抗阻训练组相对于对照组的瘦体重变化范围为-0.4%至3.9%，在6项试验中的4项中，训练效果显著大于对照组的变化。在6项非RCT中，瘦体重随时间的平均变化范围为-0.01%至11.8%，其中2项试验具有显著性。纳入研究报告称，渐进性抗阻训练后不良事件极少或非常有限。基于12项异质性研究，有中等证据支持渐进性抗阻训练对癌症治疗后患者的瘦体重有积极影响。
