血清转化生长因子-β1作为2型糖尿病肾病的生物标志物：随机对照试验的荟萃分析
Serum TGF-β1 as a Biomarker for Type 2 Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials.
作者信息
Mou Xin, Zhou Di-Yi, Zhou Dan-Yang, Ma Jing-Ru, Liu Ying-Hui, Chen Hui-Ping, Hu Yong-Bin, Shou Cheng-Min, Chen Jia-Wei, Liu Wen-Hong, Ma Guo-Ling
机构信息
Endocrinology Department, Hangzhou Red Cross Hospital, Hangzhou, 310003, China.
Zhejiang Chinese Medical University, City Road 548, Binjiang District, Hangzhou City, Zhejiang Province, 310053, China.
出版信息
PLoS One. 2016 Feb 22;11(2):e0149513. doi: 10.1371/journal.pone.0149513. eCollection 2016.
BACKGROUND
Abnormal expression of serum TGF-β1 was found in patients with diabetic nephropathy. However, the association of TGF-β1 with the risk of diabetic nephropathy remains unknown. The present study was undertaken to investigate whether such an association exists.
METHODS
We searched the Chinese VIP, Wangfang, China National Knowledge Infrastructure, PubMed, Embase, and Google Scholar databases for relevant studies and extracted all eligible data. Stata12 software was used for statistical analysis.
RESULTS
Nine reports met our criteria and were used for data extraction. There were 264 patients and 227 healthy controls from qualified reports in this meta-analysis. The results suggested that serum TGF-β1 levels were significantly up-regulated in patients with diabetic nephropathy; the instrumental variable was 3.94 (95% confidence interval 3.20-4.68, p<0.01).
CONCLUSIONS
Meta-analysis suggested that elevated serum TGF-β level in patients with diabetes is associated with a high risk of nephropathy. Further studies are required to validate these observations.
背景
糖尿病肾病患者血清转化生长因子-β1（TGF-β1）存在异常表达。然而，TGF-β1与糖尿病肾病风险之间的关联尚不清楚。本研究旨在探讨是否存在这种关联。
方法
我们检索了中国知网、万方、维普、PubMed、Embase和谷歌学术数据库中的相关研究，并提取了所有符合条件的数据。使用Stata12软件进行统计分析。
结果
9篇报告符合我们的标准并用于数据提取。本荟萃分析中，合格报告中有264例患者和227例健康对照。结果表明，糖尿病肾病患者血清TGF-β1水平显著上调；工具变量为3.94（95%置信区间3.20-4.68，p<0.01）。
结论
荟萃分析表明，糖尿病患者血清TGF-β水平升高与肾病高风险相关。需要进一步研究来验证这些观察结果。
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