Yang Bin, Xiao Bing, Sun Taoyu
Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Int J Biol Macromol. 2013 Nov;62:287-90. doi: 10.1016/j.ijbiomac.2013.09.016. Epub 2013 Sep 20.
In the present study, we investigated the antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharide (AMP) on liver cancer using murine H22 hepatocarcinoma model. The results showed that AMP (100 and 400 mg/kg) could effectively inhibit the solid tumor growth of H22 hepatocarcinoma transplanted in BALB/c mice. Besides, the body weight, spleen/thymus indexes and phagocytotic function of macrophage of H22 tumor bearing mice were also improved in two AMP treated groups. Furthermore, AMP treatment could promote the secretion of IL-2, IL-12 and TNF-α and decreased IL-10 level in serum. Taken together, these findings indicate that AMP has antitumor activity in vivo at least partly via improving immune responses of host organism, and seems to be safe and effective for the use of anti-tumor therapy.
在本研究中，我们利用小鼠H22肝癌模型研究了黄芪多糖（AMP）对肝癌的抗肿瘤和免疫调节活性。结果表明，AMP（100和400mg/kg）可有效抑制BALB/c小鼠移植的H22肝癌实体瘤生长。此外，两个AMP治疗组中荷H22肿瘤小鼠的体重、脾/胸腺指数及巨噬细胞吞噬功能也得到改善。此外，AMP治疗可促进血清中IL-2、IL-12和TNF-α的分泌，并降低IL-10水平。综上所述，这些发现表明AMP在体内具有抗肿瘤活性，至少部分是通过改善宿主机体的免疫反应实现的，并且似乎对于抗肿瘤治疗的应用是安全有效的。
