Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, PR China.
Gene. 2013 Dec 10;532(1):114-9. doi: 10.1016/j.gene.2013.09.043. Epub 2013 Sep 20.
Many epidemiological studies have indicated that interleukin-1α (IL-1α) -899 (+4845) C→T polymorphism increases the risk of chronic periodontitis (CP), whereas some studies have reported opposite results. Accordingly, the aim of this meta-analysis is to investigate the association of the IL-1α -899 (+4845) C→T polymorphism with CP. We searched the PubMed database up to May 1, 2013 and finally obtained 23 case-control studies. After data extraction, we performed meta-analysis using Comprehensive Meta-Analysis v2.2 software. The overall result based on the fixed-effect model showed that IL-1α -899 (+4845) C→T polymorphism was significantly associated with increased risk of CP: [odds ratio (OR)=1.29, 95% confidence interval (CI)=1.15-1.44, p<0.001] for T vs. C; (OR=1.59, 95%CI=1.22-2.07, p=0.0005) for TT vs. CC; (OR=1.30, 95% CI=1.12-1.51, p=0.0004) for CT vs. CC; and (OR=1.40, 95% CI=1.21-1.61, p<0.001) for (CT+TT) vs. CC; (OR=1.47, 95% CI=1.16-1.87, p=0.002) for TT vs. (CT+CC). Stratified analyses revealed that there was a significantly increased risk for Caucasians and Asians. In conclusion, current evidence showed that IL-1α -899 (+4845) C→T polymorphism probably increased the risk of CP.
许多流行病学研究表明，白细胞介素-1α（IL-1α）-899（+4845）C→T 多态性增加了慢性牙周炎（CP）的风险，而一些研究则报告了相反的结果。因此，本荟萃分析旨在研究白细胞介素-1α-899（+4845）C→T 多态性与 CP 的相关性。我们检索了PubMed 数据库，截至 2013 年 5 月 1 日，最终获得了 23 项病例对照研究。在数据提取后，我们使用 Comprehensive Meta-Analysis v2.2 软件进行了荟萃分析。基于固定效应模型的总体结果表明，IL-1α-899（+4845）C→T 多态性与 CP 的风险增加显著相关：[比值比（OR）=1.29，95%置信区间（CI）=1.15-1.44，p<0.001] T 对 C；（OR=1.59，95%CI=1.22-2.07，p=0.0005）TT 对 CC；（OR=1.30，95%CI=1.12-1.51，p=0.0004）CT 对 CC；和（OR=1.40，95%CI=1.21-1.61，p<0.001）CT+TT 对 CC；（OR=1.47，95%CI=1.16-1.87，p=0.002）TT 对（CT+CC）。分层分析显示，白种人和亚洲人风险显著增加。总之，目前的证据表明，白细胞介素-1α-899（+4845）C→T 多态性可能增加 CP 的风险。
