Inchingolo Alessio Danilo, Inchingolo Angelo Michele, Bordea Ioana Roxana, Malcangi Giuseppina, Xhajanka Edit, Scarano Antonio, Lorusso Felice, Farronato Marco, Tartaglia Gianluca Martino, Isacco Ciro Gargiulo, Marinelli Grazia, D'Oria Maria Teresa, Hazballa Denisa, Santacroce Luigi, Ballini Andrea, Contaldo Maria, Inchingolo Francesco, Dipalma Gianna
Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Department of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Microorganisms. 2021 Mar 4;9(3):525. doi: 10.3390/microorganisms9030525.
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a high-risk viral agent involved in the recent pandemic stated worldwide by the World Health Organization. The infection is correlated to a severe systemic and respiratory disease in many cases, which is clinically treated with a multi-drug pharmacological approach. The purpose of this investigation was to evaluate through a literature overview the effect of adjuvant therapies and supplements for the SARS-CoV-2 infection. The research has analyzed the advantage of the EK1C4, by also assessing the studies on the resveratrol, vitamin D, and melatonin as adjuvant supplements for long hauler patients' prognosis. The evaluated substances reported important benefits for the improvement of the immune system and as a potential inhibitor molecules against SARS-CoV-2, highlighting the use of sartans as therapy. The adjuvant supplements seem to create an advantage for the healing of the long hauler patients affected by chronic symptoms of constant chest and heart pain, intestinal disorders, headache, difficulty concentrating, memory loss, and tachycardia.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种高风险病毒病原体，世界卫生组织称其引发了近期全球大流行。在许多情况下，该感染与严重的全身性和呼吸道疾病相关，临床上采用多种药物的药理学方法进行治疗。本研究的目的是通过文献综述评估辅助疗法和补充剂对SARS-CoV-2感染的影响。该研究分析了EK1C4的优势，同时还评估了白藜芦醇、维生素D和褪黑素作为辅助补充剂对长期康复患者预后的研究。评估的物质显示出对改善免疫系统以及作为对抗SARS-CoV-2的潜在抑制剂分子具有重要益处，突出了使用沙坦类药物作为治疗方法。辅助补充剂似乎为患有持续胸痛、心痛、肠道疾病、头痛、注意力不集中、记忆力减退和心动过速等慢性症状的长期康复患者的康复创造了优势。
