aSchool of Psychology, Flinders University, Adelaide, South Australia, Australia bBiological Rhythms Research Laboratory, Rush University Medical Center, Chicago, Illinois, USA.
Curr Opin Psychiatry. 2013 Nov;26(6):580-5. doi: 10.1097/YCO.0b013e328365a1d4.
For over 30 years, delayed sleep phase disorder (DSPD) has been defined as a debilitating sleep condition. Recently, there is more awareness of DSPD in young people, yet considerable information is needed to understand its cause and treatment. This review describes the latest research findings describing the clinical features, cause, and treatment of DSPD.
The prevalence of DSPD in adolescents and young adults ranges from 1 to 16%. The impact on the individuals is significant, particularly in the domains of school/work performance and mental health. We describe various contributing factors including reduced homeostatic sleep pressure, a lengthened and delayed circadian rhythm, insensitivity to clock-resetting morning light, and heightened cognitive activity. Evening melatonin administration as a sole treatment appears promising, as is a combination of cognitive-behavior therapy and morning bright light.
Recent findings suggest clinicians to be aware of the clinical features (i.e., significant daytime sleepiness, anxiety and depression symptoms, potential for school dropout) of DSPD, as several biological features underpinning this disorder are unseen in clinical settings. We advise clinicians to become familiar with exogenous evening melatonin administration, and cognitive and behavioral techniques to simultaneously treat the delayed circadian rhythm and associated sleep-onset insomnia.
三十多年来,睡眠时相延迟障碍(DSPD)一直被定义为一种使人虚弱的睡眠障碍。最近,人们对年轻人的 DSPD 有了更多的认识,但仍需要更多的信息来了解其病因和治疗方法。本综述描述了描述 DSPD 的临床特征、病因和治疗的最新研究结果。
青少年和年轻人中 DSPD 的患病率为 1%至 16%。它对个人的影响是巨大的,特别是在学校/工作表现和心理健康方面。我们描述了各种促成因素,包括内源性睡眠压力降低、昼夜节律延长和延迟、对时钟重置晨光的敏感性降低以及认知活动增加。单独使用褪黑素夜间给药似乎很有希望,认知行为疗法和晨光疗法相结合也很有希望。
最近的研究结果表明,临床医生应该注意 DSPD 的临床特征(即明显的日间嗜睡、焦虑和抑郁症状、辍学的可能性),因为这种疾病的一些生物学特征在临床环境中是看不到的。我们建议临床医生熟悉外源性褪黑素夜间给药以及认知和行为技术,以同时治疗延迟的昼夜节律和相关的入睡困难。