School of Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
J Clin Biochem Nutr. 2013 Sep;53(2):102-7. doi: 10.3164/jcbn.13-37. Epub 2013 Aug 22.
Only a few investigations were based on limb bone density. This study evaluated the efficacy of soy isoflavone in the treatment of the principal menopausal disorders, limb bone density and the role of pathway. The research protocol involved the random subdivision of the enrolled sample into two groups of 40 women, who were to receive treatment for 6 months with isoflavone (90 mg/day) and with placebo. All of the patients were asked to fill in a questionnaire concerning their complaints. BMD of the radius and tibia were measured using quantitative ultrasound. Bone metabolism indexes calcium, phosphorus and alkaline phosphatase (ALP) were examined regularly. Serum cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) examined by ELISA. The results of the score of Kupperman table showed that the isoflavone can lead to a significant reduction in some of the disorders. Compared with placebo, the tibia bone density in isoflavone group increased obviously against the base value before trail. Isoflavone led to a stronger descent of the concentration of ALP and a decrease of IL-6 and TNF-α level than placebo. For climacteric women, soy isoflavone in the dose of 90 mg/day could improve some menopausal syndromes and was effective on increasing limb bone density, which maybe had the relationship with the levels of IL-6, TNF-α and ALP in serum.
仅有少数研究基于肢体骨密度。本研究评估了大豆异黄酮治疗主要更年期障碍、肢体骨密度和作用途径的疗效。研究方案涉及将入组样本随机分为两组，每组 40 名女性，分别接受 6 个月的异黄酮（90mg/天）和安慰剂治疗。所有患者均被要求填写一份关于其投诉的问卷。使用定量超声测量桡骨和胫骨的 BMD。定期检查钙、磷和碱性磷酸酶（ALP）等骨代谢指标。通过 ELISA 检查血清细胞因子白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。Kupperman 表评分的结果表明，异黄酮可显著降低一些疾病。与安慰剂相比，异黄酮组的胫骨骨密度与试验前的基础值相比明显增加。异黄酮导致 ALP 浓度下降和 IL-6 和 TNF-α 水平下降的作用强于安慰剂。对于更年期女性，每天 90mg 的大豆异黄酮可改善一些更年期综合征，并有效增加肢体骨密度，这可能与血清中 IL-6、TNF-α 和 ALP 的水平有关。
