Ye Yan-Bin, Tang Xing-Yi, Verbruggen Marian A, Su Yi-Xiang
Department of Nutrition, School of public Health Sun Yat-sen University, 74 Zhongshan Rd 2, Guangzhou, 510080, P.R. China.
Eur J Nutr. 2006 Sep;45(6):327-34. doi: 10.1007/s00394-006-0602-2. Epub 2006 Jun 8.
Previous studies show that daily doses of 40-99 mg soy isoflavones produce inconsistent effects on preventing estrogen-related bone loss in postmenopausal women.
To examined the bone-sparing effect of isoflavones at a higher dose in early Chinese postmenopausal women.
A total of 90 eligible women aged 45-60 years were randomly assigned to three treatment groups (30 subjects/group) with daily dosages of 0 (placebo), 84 and 126 mg isoflavones for 6 months. Further inclusion criteria included body mass index <30 kg/m(2) and Kuppermann Climacteric Scale >15. Bone mineral density (BMD) of the spine and hip were measured using dual- energy X-ray absorptiometry at 0 and 6 months. Serum osteocalcin, bone-specific alkaline phosphatase (BAP) and urinary deoxypyridinoline were examined at 0, 3 and 6 months.
Mean percent changes in BMD at the lumbar spine (p = 0.114) and femoral neck (p = 0.053) increased with the supplementations of soy isoflavones after adjusting for age, years since menopause, body weight and height, dietary intakes of isoflavones, calcium and protein, physical activities and baseline BMD at the relevant sites. We observed significantly dose-dependent linear relationship between the supplemental isoflavones and percent changes of BMD at the spine (p = 0.042) and femoral neck (p = 0.016) post-treatment, and urinary total deoxypyridinoline (p = 0.014) at 12 weeks but not at 24 weeks after adjusting for the above factors. No significant difference in percent changes in serum osteocalcin (p > 0.05) and BAP (p > 0.05) was found among the three treatment groups at 12-week and 24-week post-treatment.
There is a significantly dose-dependent effect of soy isoflavones on attenuating bone loss at the spine and femoral neck possibly via the inhibition of bone resorption in non-obese postmenopausal Chinese women with high Kuppermann Scale.
先前的研究表明，每日服用40 - 99毫克大豆异黄酮对预防绝经后女性雌激素相关的骨质流失效果不一。
研究更高剂量异黄酮对中国早期绝经后女性的骨质保护作用。
总共90名年龄在45 - 60岁的合格女性被随机分为三个治疗组（每组30名受试者），分别每日服用0（安慰剂）、84毫克和126毫克异黄酮，持续6个月。进一步的纳入标准包括体重指数<30kg/m²以及Kuppermann更年期量表评分>15。在0个月和6个月时使用双能X线吸收法测量脊柱和髋部的骨密度。在0个月、3个月和6个月时检测血清骨钙素、骨特异性碱性磷酸酶（BAP）和尿脱氧吡啶啉。
在调整年龄、绝经年限、体重、身高、异黄酮、钙和蛋白质的饮食摄入量、身体活动以及相关部位的基线骨密度后，随着大豆异黄酮补充量的增加，腰椎（p = 0.114）和股骨颈（p = 0.053）骨密度的平均百分比变化有所增加。在调整上述因素后，我们观察到治疗后补充异黄酮与脊柱（p = 0.042）和股骨颈（p = 0.016）骨密度百分比变化以及12周时尿总脱氧吡啶啉（p = 0.014）之间存在显著的剂量依赖性线性关系，但在24周时不存在。治疗后12周和24周时，三个治疗组之间血清骨钙素（p > 0.05）和BAP（p > 0.05）的百分比变化没有显著差异。
对于Kuppermann量表评分较高的非肥胖绝经后中国女性，大豆异黄酮对减轻脊柱和股骨颈骨质流失具有显著的剂量依赖性作用，可能是通过抑制骨吸收实现的。
