Department of Neurology, University of Pennsylvania Philadelphia, PA, USA ; Center for Cognitive Neuroscience, University of Pennsylvania Philadelphia, PA, USA.
Front Psychol. 2013 Sep 11;4:571. doi: 10.3389/fpsyg.2013.00571. eCollection 2013.
While converging evidence implicates the right inferior parietal lobule in audiovisual integration, its role has not been fully elucidated by direct manipulation of cortical activity. Replicating and extending an experiment initially reported by Kamke et al. (2012), we employed the sound-induced flash illusion, in which a single visual flash, when accompanied by two auditory tones, is misperceived as multiple flashes (Wilson, 1987; Shams et al., 2000). Slow repetitive (1 Hz) TMS administered to the right angular gyrus, but not the right supramarginal gyrus, induced a transient decrease in the Peak Perceived Flashes (PPF), reflecting reduced susceptibility to the illusion. This finding independently confirms that perturbation of networks involved in multisensory integration can result in a more veridical representation of asynchronous auditory and visual events and that cross-modal integration is an active process in which the objective is the identification of a meaningful constellation of inputs, at times at the expense of accuracy.
虽然越来越多的证据表明右下顶叶在视听整合中起作用，但通过直接操纵皮质活动，其作用尚未完全阐明。我们复制并扩展了 Kamke 等人（2012 年）最初报道的实验，采用了声音诱导的闪光错觉，即当单个视觉闪光伴随着两个听觉音调时，会被错误地感知为多个闪光（Wilson，1987；Shams 等人，2000）。给予右角回（angular gyrus）而不是右缘上回（supramarginal gyrus）缓慢重复（1 Hz）TMS 会导致 Peak Perceived Flashes（PPF）短暂下降，反映出对错觉的敏感性降低。这一发现独立证实了，对涉及多感觉整合的网络的干扰会导致对异步听觉和视觉事件的更真实的表示，并且跨模态整合是一个主动的过程，其目的是识别有意义的输入组合，有时以牺牲准确性为代价。
