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化疗耐药与癌症相关炎症：由非典型联系蛋白PKCζ连接的癌症两大特征

Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ.

作者信息

Rimessi Alessandro, Patergnani Simone, Ioannidi Elli, Pinton Paolo

机构信息

Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), Department of Morphology, Surgery and Experimental Medicine, Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara , Ferrara , Italy.

出版信息

Front Oncol. 2013 Sep 12;3:232. doi: 10.3389/fonc.2013.00232.

DOI:10.3389/fonc.2013.00232
PMID:24062985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3770915/
Abstract

Atypical protein kinase C isoforms are serine threonine kinases involved in various pathological conditions. In recent years, the PKCζ isoform has emerged as an important regulator of multiple cellular processes operating in cancer. In this review, we will focus on the PKCζ isoform as an oxidative-sensing kinase involved in cancer-related inflammation and chemoresistance. We will discuss its nuclear localization and its possible pivotal role in connecting inflammation with drug resistance.

摘要

非典型蛋白激酶C亚型是参与多种病理状况的丝氨酸苏氨酸激酶。近年来，PKCζ亚型已成为癌症中多种细胞过程的重要调节因子。在本综述中，我们将重点关注PKCζ亚型作为一种参与癌症相关炎症和化疗耐药性的氧化感应激酶。我们将讨论其核定位以及在连接炎症与耐药性方面可能的关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca8/3770915/bc68520913ad/fonc-03-00232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca8/3770915/d2f8db43329f/fonc-03-00232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca8/3770915/bc68520913ad/fonc-03-00232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca8/3770915/d2f8db43329f/fonc-03-00232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca8/3770915/bc68520913ad/fonc-03-00232-g002.jpg

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