Gamboa Ricardo, Huesca-Gómez Claudia, López-Pérez Vanessa, Posadas-Sánchez Rosalinda, Cardoso-Saldaña Guillermo, Medina-Urrutia Aida, Juárez-Rojas Juan Gabriel, Soto María Elena, Posadas-Romero Carlos, Vargas-Alarcón Gilberto
Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico D.F., Mexico.
Department of Endocrinology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico D.F., Mexico.
Genet Mol Biol. 2018;41(2):371-378. doi: 10.1590/1678-4685-GMB-2017-0008. Epub 2018 May 21.
We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc = 0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patients with the UCP3 -55 (rs1800849) TT presented high levels of VAF (Pc = 0.002). The results suggest the association of the UCP2 -866 (rs659366) polymorphism with risk of developing pCAD. Some polymorphisms were associated with abdominal fat levels and cardiovascular risk factors.
我们研究了解偶联蛋白（UCP）基因多态性作为早发性冠状动脉疾病（pCAD）易感性标志物的作用。对948例pCAD患者和763例对照进行了UCP2 Ala55Val（C/T rs660339）、UCP2 -866G/A（rs659366）和UCP3 -55C/T（rs1800849）多态性的基因分型。pCAD患者和对照中UCP2 A55V（C/T rs660339）和UCP3 -55（rs1800849）的分布相似。然而，在隐性模型下，UCP2 -866（rs659366）A等位基因与发生pCAD的风险增加相关（比值比[OR]=1.43，校正P值[Pc]=0.003）。另一方面，pCAD患者且UCP2 A55V（rs660339）为TT型者显示出高水平的内脏腹部脂肪（VAF）（Pc=0.002）、低水平的皮下腹部脂肪（SAF）（Pc=0.001）和高VAT/SAT比值（Pc<0.001）。此外，UCP2 -866（rs659366）为AA型的患者显示VAF水平升高（Pc=0.003）、SAF水平降低（Pc=0.001）和高VAT/SAT比值（Pc=0.002），而UCP3 -55（rs1800849）为TT型的患者呈现高水平的VAF（Pc=0.002）。结果提示UCP2 -866（rs659366）多态性与发生pCAD的风险相关。一些多态性与腹部脂肪水平和心血管危险因素相关。
