University of Milan, Department of Clinical Sciences and Community Health, Milan, Italy.
Invest Ophthalmol Vis Sci. 2013 Oct 17;54(10):6841-5. doi: 10.1167/iovs.13-12761.
We analyzed choroidal volume (CV) variations during childhood using enhanced depth imaging optical coherence tomography, and evaluated its association with age, axial length (AXL), sex, weight, and height.
Imaging studies of the right eyes of 52 healthy children were reviewed and included in this study. Subjects underwent a complete ocular examination and AXL measurement, as well as a raster macular scan using the Heidelberg Spectralis device. The choroid was segmented manually.
Subjects included 21 males and 31 females, with mean age of 9 years (range, 2-17 years) and mean AXL of 22.8 ± 0.98 mm. Mean CV was 0.263 ± 0.068 mm(3) for the foveal circle and 8.545 ± 1.822 mm(3) for the total Early Treatment of Diabetic Retinopathy Study (ETDRS) grid. The CV of the nasal quadrant was significantly lower than all others (P < 0.001). Total and foveal CV showed significant negative correlation with AXL after adjustment for age (P < 0.001), and significant positive correlation with age after adjustment for AXL (P < 0.001). Total CV was correlated significantly with sex after adjusting for AXL (P = 0.01), while no correlations were found between total CV and height or weight. The CV increased by 0.214 mm(3) (2.5%) for every year, and decreased by 1.0 mm(3) (11.7%) for every millimeter of axial length. Regression analysis confirmed a trend of higher CV in females than in males (P = 0.056).
The CV increases with age during childhood, but decreases with AXL. This finding supports the hypothesis that the choroid grows progressively during childhood. Intersexual differences of CV also may be present.
我们使用增强深度成像光学相干断层扫描分析了儿童期脉络膜体积（CV）的变化，并评估了其与年龄、眼轴（AXL）、性别、体重和身高的相关性。
回顾性分析了 52 名健康儿童右眼的影像学研究资料，并将其纳入本研究。所有受试者均接受了全面的眼部检查和 AXL 测量，以及使用海德堡 Spectralis 设备进行黄斑 raster 扫描。脉络膜采用手动分割。
受试者包括 21 名男性和 31 名女性，平均年龄为 9 岁（范围 2-17 岁），平均 AXL 为 22.8±0.98mm。黄斑中心凹 0.263±0.068mm³（foveal circle）和 ETDRS 全网格 8.545±1.822mm³（total ETDRS grid）的 CV 平均值分别为 0.263±0.068mm³ 和 8.545±1.822mm³。鼻象限的 CV 明显低于其他象限（P<0.001）。调整年龄后，总 CV 和黄斑中心凹 CV 与 AXL 呈显著负相关（P<0.001），调整 AXL 后与年龄呈显著正相关（P<0.001）。调整 AXL 后，总 CV 与性别显著相关（P=0.01），而总 CV 与身高或体重无相关性。CV 每年增加 0.214mm³（2.5%），眼轴每增加 1mm（11.7%）则减少 1.0mm³。回归分析证实女性 CV 高于男性的趋势（P=0.056）。
儿童期 CV 随年龄增长而增加，但随 AXL 减少而减少。这一发现支持脉络膜在儿童期逐渐生长的假说。CV 的性别差异也可能存在。
