Department of Chemistry, York University , 4700 Keele Street, Toronto, Ontario Canada M3J 1P3.
J Am Chem Soc. 2013 Oct 30;135(43):16042-5. doi: 10.1021/ja4086269. Epub 2013 Sep 30.
We present a sensing platform based on the morphological changes of plasmonic nanoparticles. Detection is achieved by using a stimulus-responsive polyelectrolyte-aptamer thin film to control the rate of diffusion of etchants that alter the shape and size of the nanoparticles. We show that the extent of morphological change and the colorimetric response depends on the amount of analyte bound. Contrary to conventional plasmonic sensors, our detection scheme does not rely on any interparticle interaction and is completely label-free, both in terms of the analyte and the capture probe. It presents new opportunities for designing facile, low-cost, and portable chip-based sensors for biodiagnostic and field analysis.
我们提出了一种基于等离子体纳米粒子形态变化的传感平台。通过使用对刺激响应的聚电解质-适体薄膜来控制蚀刻剂的扩散速率来实现检测，这会改变纳米粒子的形状和大小。我们表明，形态变化的程度和比色响应取决于结合的分析物的量。与传统的等离子体传感器不同，我们的检测方案不依赖于任何颗粒间相互作用，并且在分析物和捕获探针方面都是完全无标记的。它为设计用于生物诊断和现场分析的简便、低成本和便携式基于芯片的传感器提供了新的机会。
