Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Biosens Bioelectron. 2018 Aug 30;114:52-65. doi: 10.1016/j.bios.2018.05.015. Epub 2018 May 9.
Plasmonic colorimetric sensors have emerged as a powerful tool in chemical and biological sensing applications due to the localized surface plasmon resonance (LSPR) extinction in the visible range. Among the plasmonic sensors, the most famous sensing mode is the "aggregation" plasmonic colorimetric sensor which is based on plasmon coupling due to nanoparticle aggregation. Herein, this review focuses on the newly-developing plasmonic colorimetric sensing mode - the etching or the growth of metal nanoparticles induces plasmon changes, namely, "non-aggregation" plasmonic colorimetric sensor. This type of sensors has attracted increasing interest because of their exciting properties of high sensitivity, multi-color changes, and applicability to make a test strip. Of particular interest, the test strip by immobilization of nanoparticles on the substrate can avoid the influence of nanoparticle auto-aggregation and increase the simplicity in storage and use. Although there are many excellent reviews available that describe the advance of plasmonic sensors, limited attention has been paid to the plasmonic colorimetric sensors based on etching or growth of metal nanoparticles. This review highlights recent progress on strategies and application of "non-aggregation" plasmonic colorimetric sensors. We also provide some personal insights into current challenges associated with "non-aggregation" plasmonic colorimetric sensors and propose future research directions.
等离子体颜色传感器由于在可见范围内的局域表面等离子体共振（LSPR）消光而成为化学和生物传感应用中的强大工具。在等离子体传感器中，最著名的传感模式是基于纳米颗粒聚集的等离子体耦合的“聚集”等离子体颜色传感器。本文综述了新开发的等离子体颜色传感模式-金属纳米颗粒的蚀刻或生长引起的等离子体变化，即“非聚集”等离子体颜色传感器。由于其高灵敏度、多色变化和适用于制作测试条的特性，这种传感器引起了越来越多的关注。特别感兴趣的是，通过将纳米颗粒固定在基底上的测试条可以避免纳米颗粒自聚集的影响，并增加存储和使用的简单性。尽管有许多优秀的综述描述了等离子体传感器的进展，但对基于金属纳米颗粒的蚀刻或生长的等离子体颜色传感器的关注有限。本文重点介绍了“非聚集”等离子体颜色传感器的策略和应用的最新进展。我们还对“非聚集”等离子体颜色传感器相关的当前挑战提供了一些个人见解，并提出了未来的研究方向。
