Department of Health Science, Brigham Young University, Provo, UT (BTC); the Population Studies Center, University of Pennsylvania, Philadelphia, PA (WS); the Grupo de Analisis para el Desarrollo, Lima, Peru (SC); the Boston University Department of International Health and Center for Global Health and Development, Boston, MA (KAD); the Department of Psychology and Child Development, Cal Poly State University, San Luis Obispo, CA (PE); the Young Lives study, Department of International Development, University of Oxford, Oxford, United Kingdom (AG); the Nutrition and Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA (EAL); the Instituto de Investigación Nutricional, Lima, Peru (MEP); the Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA (ADS); and the Economics and Sociology Departments and Population Studies Center, University of Pennsylvania, Philadelphia, PA (JRB).
Am J Clin Nutr. 2013 Dec;98(6):1555-63. doi: 10.3945/ajcn.113.067561. Epub 2013 Sep 25.
Early life growth failure and resulting cognitive deficits are often assumed to be very difficult to reverse after infancy.
We used data from Young Lives, which is an observational cohort of 8062 children in Ethiopia, India, Peru, and Vietnam, to determine whether changes in growth after infancy are associated with schooling and cognitive achievement at age 8 y.
We represented the growth by height-for-age z score at 1 y [HAZ(1)] and height-for-age z score at 8 y that was not predicted by the HAZ(1). We also characterized growth as recovered (stunted at age 1 y and not at age 8 y), faltered (not stunted at age 1 y and stunted at age 8 y), persistently stunted (stunted at ages 1 and 8 y), or never stunted (not stunted at ages 1 and 8 y). Outcome measures were assessed at age 8 y.
The HAZ(1) was inversely associated with overage for grade and positively associated with mathematics achievement, reading comprehension, and receptive vocabulary. Unpredicted growth from 1 to 8 y of age was also inversely associated with overage for grade (OR range across countries: 0.80-0.84) and positively associated with mathematics achievement (effect-size range: 0.05-0.10), reading comprehension (0.02-0.10), and receptive vocabulary (0.04-0.08). Children who recovered in linear growth had better outcomes than did children who were persistently stunted but were not generally different from children who experienced growth faltering.
Improvements in child growth after early faltering might have significant benefits on schooling and cognitive achievement. Hence, although early interventions remain critical, interventions to improve the nutrition of preprimary and early primary school-age children also merit consideration.
婴幼儿期生长发育迟缓及由此导致的认知缺陷,通常被认为在婴幼儿期之后很难逆转。
我们利用来自 Young Lives 的数据,该研究是对埃塞俄比亚、印度、秘鲁和越南 8062 名儿童进行的一项观察性队列研究,以确定婴幼儿期后生长的变化是否与 8 岁时的学校教育和认知成绩有关。
我们用一岁时的身高年龄 z 评分(HAZ(1))和 8 岁时的身高年龄 z 评分(HAZ(8))来表示生长情况,后者不能由 HAZ(1)来预测。我们还将生长情况描述为恢复型(1 岁时发育迟缓但 8 岁时不发育迟缓)、迟滞型(1 岁时不发育迟缓但 8 岁时发育迟缓)、持续发育迟缓型(1 岁和 8 岁时均发育迟缓)或从未发育迟缓型(1 岁和 8 岁时均不发育迟缓)。我们在 8 岁时评估了结果测量值。
HAZ(1)与年级偏高呈负相关,与数学成绩、阅读理解和接受性词汇呈正相关。1 岁至 8 岁期间未预测到的生长情况也与年级偏高呈负相关(各国范围的比值比为 0.80-0.84),与数学成绩(效应大小范围为 0.05-0.10)、阅读理解(0.02-0.10)和接受性词汇(0.04-0.08)呈正相关。线性生长恢复的儿童比持续发育迟缓的儿童有更好的结果,但通常与生长迟滞的儿童没有差异。
儿童在早期迟滞后生长情况的改善可能对学校教育和认知成绩有显著益处。因此,虽然早期干预仍然至关重要,但改善学前和小学早期儿童营养的干预措施也值得考虑。