Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Rheumatology (Oxford). 2014 May;53(5):777-84. doi: 10.1093/rheumatology/ket319. Epub 2013 Sep 24.
The resident microbial community, harboured by humans in sites such as the skin and gastrointestinal tract, is enormous, representing a candidate environmental factor affecting susceptibility to complex diseases, where both genetic and environmental risk factors are important. The potential of microorganisms to influence the human immune system is considerable, given their ubiquity. The impact of the host-gene-microbe interaction on the maintenance of health and the development of disease has not yet been assessed robustly in chronic inflammatory conditions. PsA represents a model inflammatory disease to explore the role of the microbiome because skin involvement and overlap with IBD implicates both the skin and gastrointestinal tract as sources of microbial triggers for PsA. In parallel with genetic studies, characterization of the host microbiota may benefit our understanding of the microbial contribution to disease pathogenesis-knowledge that may eventually inform the development of novel therapeutics.
人体的寄居微生物群落存在于皮肤和胃肠道等部位，数量庞大，是影响复杂疾病易感性的候选环境因素之一，遗传和环境风险因素都很重要。鉴于微生物无处不在，它们对人类免疫系统的影响是相当大的。宿主-基因-微生物相互作用对维持健康和疾病发展的影响在慢性炎症性疾病中尚未得到有力评估。PsA 是一种炎症性疾病模型，可用于探索微生物组的作用，因为皮肤受累和与 IBD 的重叠提示皮肤和胃肠道都是引发 PsA 的微生物来源。与遗传研究并行，宿主微生物组的特征分析可能有助于我们了解微生物对疾病发病机制的贡献——这些知识最终可能为新型治疗方法的开发提供信息。
