脂肪组织在银屑病和银屑病关节炎中的局部作用。
Local effects of adipose tissue in psoriasis and psoriatic arthritis.
作者信息
Kruglikov Ilja L, Wollina Uwe
机构信息
Scientific Department, Wellcomet GmbH, Karlsruhe.
Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.
出版信息
Psoriasis (Auckl). 2017 Feb 3;7:17-25. doi: 10.2147/PTT.S122959. eCollection 2017.
The structure and physiological state of the local white adipose tissue (WAT) located underneath the lesional psoriatic skin and inside of the joints affected by psoriatic arthritis play an important role in the pathophysiology of these diseases. WAT pads associated with inflammatory sites in psoriasis and psoriatic arthritis are, correspondingly, dermal WAT and articular adipose tissue; these pads demonstrate inflammatory phenotypes in both diseases. Such local WAT inflammation could be the primary effect in the pathophysiology of psoriasis leading to the modification of the local expression of adipokines, a change in the structure of the basement membrane and the release of keratinocytes with consequent epidermal hyperproliferation during psoriasis. Similar articular adipose tissue inflammation can lead to the induction of structural modifications and synovial inflammation in the joints of patients with psoriatic arthritis.
位于银屑病皮损下方以及银屑病关节炎受累关节内部的局部白色脂肪组织（WAT）的结构和生理状态在这些疾病的病理生理学中起着重要作用。与银屑病和银屑病关节炎炎症部位相关的WAT垫分别是真皮WAT和关节脂肪组织；这些垫在两种疾病中均表现出炎症表型。这种局部WAT炎症可能是银屑病病理生理学中的主要效应，导致脂肪因子局部表达的改变、基底膜结构的变化以及角质形成细胞的释放，进而在银屑病期间导致表皮过度增殖。类似的关节脂肪组织炎症可导致银屑病关节炎患者关节的结构改变和滑膜炎。
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