BlastGraph：基于 BLAST 和图算法的比较基因组学工具。
BlastGraph: a comparative genomics tool based on BLAST and graph algorithms.
机构信息
Key Laboratory of Agricultural and Environmental Microbiology, Wuhan Institute of Virology, Wuhan, Hubei, China, 430071, Graduate School of Chinese Academy of Sciences, Beijing, China and Exiqon A/S, Vedbaek, Denmark.
出版信息
Bioinformatics. 2013 Dec 15;29(24):3222-4. doi: 10.1093/bioinformatics/btt553. Epub 2013 Sep 24.
UNLABELLED
BlastGraph is an interactive Java program for comparative genome analysis based on Basic Local Alignment Search Tool (BLAST), graph clustering and data visualization. The software generates clusters of sequences of multiple genomes from all-to-all BLAST results and visualizes the results in graph plots together with related information such as sequence features, gene conservation and similarity relationships. Pruning algorithms are used to reduce results to more meaningful subclusters. Subsequent analyses can then be conducted based on the predicted clusters, including gene content, genome phylogenetics and gene gain and loss.
AVAILABILITY AND IMPLEMENTATION
未标记
BlastGraph 是一个基于基本局部比对搜索工具（BLAST）、图形聚类和数据可视化的交互式 Java 程序，用于比较基因组分析。该软件从全对全 BLAST 结果中生成多个基因组序列的簇，并将结果与相关信息（如序列特征、基因保守性和相似性关系）一起以图形形式可视化。修剪算法用于将结果简化为更有意义的子簇。然后可以根据预测的簇进行后续分析，包括基因组成、基因组系统发育和基因增益和丢失。
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