Lipnharski Caroline, d'Azevedo Pedro Alves, Quinto Vanessa Petry, Bessa Giancarlo, Bonamigo Renan Rangel
Universidade de Ciências da Saúde de Porto Alegre, Porto AlegreRSBrazil.
An Bras Dermatol. 2013 Jul-Aug;88(4):518-21. doi: 10.1590/abd1806-4841.20132046.
Atopic dermatitis leads to epidermal barrier dysfunction and bacteria colonization. The relationship of the last factor with the severity of the disease and the frequency of exacerbation is not fully known.
Verify the severity of the atopic dermatitis and the number of appointments generated by dermatosis, comparing patients colonized with patients not colonized by S. aureus. Verify the frequency of colonization by methicillin resistant Staphylococcus aureus acquired in the community.
Cohort study with a 12 months follow-up, in a sample of patients from Porto Alegre, RS public network. Cultures in active injuries and nasal cavities were carried out as well as methicillin sensitivity tests to S. aureus. The severity of atopic dermatitis was defined by Eczema Area and Severity Index (EASI).
We included 93 patients, 43% female and 56% male, 26 colonized by S. aureus in the nasal orifices, 56 in the skin damage. The mean of initial Eczema Area and Severity Index was 5.5 and final 3.9. The initial Eczema Area and Severity Index of patients colonized by S. aureus in the skin and nasal cavity was larger than the number of patients without colonization(p< 0.05). During the period of one year, in average, there were six appointments/patient. There was linear correlation between the number of appointments during one year and the inicial Eczema Area and Severity Index (r = 0,78). There were no patients with methicillin resistant Staphylococcus aureus acquired in the community.
There is a relevant influence of staphylococcal colonization on the severity of atopic dermatitis and the number of appointments required by its exacerbation. Methicillin resistance among those affected by S. aureus does not seem to be an emergent problem, in this Brazilian sample.
特应性皮炎会导致表皮屏障功能障碍和细菌定植。最后一个因素与疾病严重程度和加重频率之间的关系尚不完全清楚。
比较金黄色葡萄球菌定植患者和未定植患者的特应性皮炎严重程度以及皮肤病导致的就诊次数。核实社区获得性耐甲氧西林金黄色葡萄球菌的定植频率。
对来自南里奥格兰德州阿雷格里港公共卫生网络的患者样本进行为期12个月的队列研究。对活动性损伤和鼻腔进行培养，并对金黄色葡萄球菌进行甲氧西林敏感性试验。特应性皮炎的严重程度由湿疹面积和严重程度指数（EASI）定义。
我们纳入了93例患者，其中43%为女性，56%为男性，26例鼻腔中有金黄色葡萄球菌定植，56例皮肤损伤中有定植。初始湿疹面积和严重程度指数的平均值为5.5，最终为3.9。皮肤和鼻腔中金黄色葡萄球菌定植患者的初始湿疹面积和严重程度指数高于未定植患者（p<0.05）。在一年期间，平均每位患者有6次就诊。一年中的就诊次数与初始湿疹面积和严重程度指数之间存在线性相关性（r = 0.78）。没有社区获得性耐甲氧西林金黄色葡萄球菌感染的患者。
葡萄球菌定植对特应性皮炎的严重程度及其加重所需的就诊次数有显著影响。在这个巴西样本中，受金黄色葡萄球菌感染的患者中耐甲氧西林情况似乎不是一个突出问题。
