Lebon Ankie, Labout Joost A M, Verbrugh Henri A, Jaddoe Vincent W V, Hofman Albert, van Wamel Willem J B, van Belkum Alex, Moll Henriëtte A
Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, University Medical Center, PO Box 2060, 3000 CB Rotterdam, The Netherlands.
Arch Pediatr Adolesc Med. 2009 Aug;163(8):745-9. doi: 10.1001/archpediatrics.2009.117.
To study the association between Staphylococcus aureus nasal colonization and atopic dermatitis (AD) in infancy.
Population-based prospective cohort study of pregnant women and their children.
This project was embedded in the Generation R Study.
A total of 1079 postnatal Dutch infants/children participated in the focus cohort. Main Exposures Nasal swabs for S aureus cultivation were taken at ages 1.5, 6, and 14 months. Main Outcome Measure Questionnaires that pertain to AD and confounders (birth weight, gestational age, sex, and parental eczema) were completed prenatally and postnatally. The outcome was AD in the first and second years of life.
A first positive culture for S aureus at age 6 months was associated with AD prevalence in the first and second years of life (adjusted odds ratio [aOR], 2.13; 95% confidence interval [CI], 1.17-3.87; and aOR, 2.88; 95% CI, 1.60-5.19, respectively) and also with severity (aOR, 3.27; 95% CI, 1.30-8.03). Moreover, frequent colonization in the first year of life (>/=2 times) held a 4.29-fold (95% CI, 1.03- to 17.88-fold) risk of moderate to severe AD in the second year of life.
Colonization with S aureus at age 6 months and frequent colonization in the first year of life are associated with AD and its severity in young children.
研究婴儿期金黄色葡萄球菌鼻腔定植与特应性皮炎（AD）之间的关联。
基于人群的孕妇及其子女前瞻性队列研究。
本项目纳入了代际R研究。
共有1079名荷兰产后婴儿/儿童参与了重点队列研究。主要暴露因素在1.5、6和14月龄时采集鼻拭子进行金黄色葡萄球菌培养。主要结局指标有关AD和混杂因素（出生体重、胎龄、性别和父母湿疹）的问卷在产前和产后完成。结局为生命第一年和第二年发生AD。
6月龄时首次金黄色葡萄球菌培养阳性与生命第一年和第二年的AD患病率相关（校正比值比[aOR]分别为2.13；95%置信区间[CI]为1.17 - 3.87；以及aOR为2.88；95%CI为1.60 - 5.19），也与疾病严重程度相关（aOR为3.27；95%CI为1.30 - 8.03）。此外，生命第一年频繁定植（≥2次）使生命第二年发生中度至重度AD的风险增加4.29倍（95%CI为1.03至17.88倍）。
6月龄时金黄色葡萄球菌定植以及生命第一年频繁定植与幼儿AD及其严重程度相关。
