• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

果蝇的JAK-STAT信号通路。

The Drosophila JAK-STAT pathway.

作者信息

Zeidler Martin P, Bausek Nina

机构信息

MRC Centre for Development and Biomedical Genetics and the Department of Biomedical Science; The University of Sheffield; Sheffield, UK.

出版信息

JAKSTAT. 2013 Jul 1;2(3):e25353. doi: 10.4161/jkst.25353. Epub 2013 Aug 1.

DOI:10.4161/jkst.25353
PMID:24069564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3772116/
Abstract

The conservation of signaling cascades between humans and Drosophila, over more than 500 million years of evolutionary time, means that the genetic tractability of the fly can be used to its full advantage to understand the functional requirements for JAK-STAT pathway signaling across species. Here we review the background to how the pathway was first identified and the first characterization of JAK-STAT pathway phenotypes in the Drosophila system, highlighting the molecular, functional, and disease-related conservation of the pathway.

摘要

在超过5亿年的进化时间里，人类和果蝇之间信号级联的保守性意味着果蝇的遗传易处理性可以被充分利用，以了解跨物种JAK-STAT信号通路的功能需求。在这里，我们回顾该信号通路最初是如何被发现的背景，以及果蝇系统中JAK-STAT信号通路表型的首次特征描述，强调该信号通路在分子、功能和疾病方面的保守性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0c2/3772116/7f9d3f0d6f89/jkst-2-e25353-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0c2/3772116/99793794f0ac/jkst-2-e25353-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0c2/3772116/21b5112c8165/jkst-2-e25353-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0c2/3772116/3803c8cd08cd/jkst-2-e25353-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0c2/3772116/7f9d3f0d6f89/jkst-2-e25353-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0c2/3772116/99793794f0ac/jkst-2-e25353-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0c2/3772116/21b5112c8165/jkst-2-e25353-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0c2/3772116/3803c8cd08cd/jkst-2-e25353-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0c2/3772116/7f9d3f0d6f89/jkst-2-e25353-g4.jpg

相似文献

1
The Drosophila JAK-STAT pathway.果蝇的JAK-STAT信号通路。
JAKSTAT. 2013 Jul 1;2(3):e25353. doi: 10.4161/jkst.25353. Epub 2013 Aug 1.
2
Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.果蝇 Jak/STAT 信号通路：在人类癌症和转移中的调控及相关性。
Int J Mol Sci. 2018 Dec 14;19(12):4056. doi: 10.3390/ijms19124056.
3
Tools and methods for studying the Drosophila JAK/STAT pathway.研究果蝇JAK/STAT信号通路的工具和方法。
Methods. 2014 Jun 15;68(1):160-72. doi: 10.1016/j.ymeth.2014.03.023. Epub 2014 Mar 28.
4
Reduction of Lobe leads to TORC1 hypoactivation that induces ectopic Jak/STAT signaling to impair Drosophila eye development.叶缺失导致 TORC1 活性降低，进而诱导 Jak/STAT 信号转导异常，损害果蝇眼睛发育。
Mech Dev. 2009 Oct;126(10):781-90. doi: 10.1016/j.mod.2009.08.005. Epub 2009 Sep 4.
5
GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo.绿色荧光蛋白报告基因可在体内检测果蝇JAK/STAT信号通路的激活情况。
Gene Expr Patterns. 2007 Jan;7(3):323-31. doi: 10.1016/j.modgep.2006.08.003. Epub 2006 Aug 22.
6
JAK/Stat signaling regulates heart precursor diversification in Drosophila.JAK/Stat 信号通路调控果蝇心脏前体细胞的多样化。
Development. 2011 Nov;138(21):4627-38. doi: 10.1242/dev.071464. Epub 2011 Sep 28.
7
Modulation of human JAK-STAT pathway signaling by functionally conserved regulators.功能保守的调节因子对人类JAK-STAT信号通路的调控
JAKSTAT. 2012 Jan 1;1(1):34-43. doi: 10.4161/jkst.18006.
8
Eye transformer is a negative regulator of Drosophila JAK/STAT signaling.眼转化器是果蝇 JAK/STAT 信号的负调控因子。
FASEB J. 2010 Nov;24(11):4467-79. doi: 10.1096/fj.10-162784. Epub 2010 Jul 12.
9
The Polyhomeotic protein induces hyperplastic tissue overgrowth through the activation of the JAK/STAT pathway.多效同源盒蛋白通过激活 JAK/STAT 通路诱导组织过度增生。
Cell Cycle. 2009 Dec 15;8(24):4103-11. doi: 10.4161/cc.8.24.10212. Epub 2009 Dec 30.
10
Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand.果蝇JAK/STAT信号通路配体Upd2的特性分析
Dev Biol. 2005 Dec 15;288(2):420-33. doi: 10.1016/j.ydbio.2005.09.040. Epub 2005 Nov 7.

引用本文的文献

1
Regulation of somatic stem cell and niche precursor fates and proliferation of by Wnt, JAK-STAT, Hedgehog and Hippo/Yorkie pathways during Drosophila pupal ovary development resembles the signaling framework organizing adult stem cell behavior.在果蝇蛹期卵巢发育过程中，Wnt、JAK-STAT、Hedgehog和Hippo/Yorkie信号通路对体细胞干细胞和微环境前体细胞命运及增殖的调控，类似于组织成体干细胞行为的信号框架。
bioRxiv. 2025 May 13:2025.05.08.652870. doi: 10.1101/2025.05.08.652870.
2
Role of Hemocytes in the Aging of Drosophila Male Germline.血细胞在果蝇雄性生殖系衰老中的作用
Cells. 2025 Feb 19;14(4):315. doi: 10.3390/cells14040315.
3

本文引用的文献

1
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : III. Zygotic loci on the X-chromosome and fourth chromosome.影响黑腹果蝇幼虫表皮模式的突变：III. X染色体和第四条染色体上的合子基因座
Wilehm Roux Arch Dev Biol. 1984 Sep;193(5):296-307. doi: 10.1007/BF00848158.
2
Localized requirements for gene activity in segmentation of Drosophila embryos: analysis of armadillo, fused, giant and unpaired mutations in mosaic embryos.果蝇胚胎分节过程中基因活性的局部需求：嵌合胚胎中犰狳、融合、巨人和无配对基因突变的分析
Rouxs Arch Dev Biol. 1986 Jan;195(1):49-62. doi: 10.1007/BF00444041.
3
Localised JAK/STAT pathway activation is required for Drosophila wing hinge development.
Host JAK-STAT activity is a target of parasitoid wasp virulence strategies.
宿主 JAK-STAT 活性是寄生蜂毒力策略的靶标。
PLoS Pathog. 2024 Jul 1;20(7):e1012349. doi: 10.1371/journal.ppat.1012349. eCollection 2024 Jul.
4
Fat- and sugar-induced signals regulate sweet and fat taste perception in Drosophila.脂肪和糖诱导的信号调节果蝇的甜和脂肪味觉感知。
Cell Rep. 2023 Nov 28;42(11):113387. doi: 10.1016/j.celrep.2023.113387. Epub 2023 Nov 6.
5
Excreted secreted products from the parasitic nematode Steinernema carpocapsae manipulate the Drosophila melanogaster immune response.寄生性线虫斯氏线虫排出的分泌产物可操纵果蝇的免疫反应。
Sci Rep. 2022 Aug 20;12(1):14237. doi: 10.1038/s41598-022-18722-7.
6
Spatiotemporal gating of Stat nuclear influx by Npas4 in collective cell migration.Npas4 对 Stat 核内流的时空门控作用在细胞集体迁移中。
Sci Adv. 2022 Jul 22;8(29):eabm2411. doi: 10.1126/sciadv.abm2411.
7
Injury-induced inflammatory signaling and hematopoiesis in .损伤诱导的炎症信号和造血作用于 。
Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2119109119. doi: 10.1073/pnas.2119109119. Epub 2022 Mar 14.
8
Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in .蛋白酶体 α6 亚基负调控 JAK/STAT 通路和血细胞激活。
Front Immunol. 2021 Dec 22;12:729631. doi: 10.3389/fimmu.2021.729631. eCollection 2021.
9
Intrinsic and damage-induced JAK/STAT signaling regulate developmental timing by the Drosophila prothoracic gland.内在的和损伤诱导的 JAK/STAT 信号通过果蝇前胸腺调节发育时间。
Dis Model Mech. 2022 Jan 1;15(1). doi: 10.1242/dmm.049160. Epub 2022 Jan 26.
10
Sending Out Alarms: A Perspective on Intercellular Communications in Insect Antiviral Immune Response.发出警报：昆虫抗病毒免疫反应中细胞间通讯的新视角。
Front Immunol. 2021 Feb 23;12:613729. doi: 10.3389/fimmu.2021.613729. eCollection 2021.
果蝇翅铰链发育需要局部 JAK/STAT 通路的激活。
PLoS One. 2013 May 31;8(5):e65076. doi: 10.1371/journal.pone.0065076. Print 2013.
4
Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion.果蝇细胞因子非配对 2 通过远程控制胰岛素分泌来调节生理稳态。
Cell. 2012 Sep 28;151(1):123-37. doi: 10.1016/j.cell.2012.08.019.
5
Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model.利用果蝇上皮转化模型鉴定 SOCS 家族蛋白和 EGFR 之间的致癌协同作用。
Genes Dev. 2012 Jul 15;26(14):1602-11. doi: 10.1101/gad.192021.112.
6
The JAK-STAT pathway at twenty.JAK-STAT 通路研究进展 20 年
Immunity. 2012 Apr 20;36(4):503-14. doi: 10.1016/j.immuni.2012.03.013.
7
The Jak/STAT pathway.Jak/STAT 通路。
Cold Spring Harb Perspect Biol. 2012 Mar 1;4(3):a011205. doi: 10.1101/cshperspect.a011205.
8
Drosophila SOCS Proteins.果蝇细胞因子信号转导抑制蛋白
J Signal Transduct. 2011;2011:894510. doi: 10.1155/2011/894510. Epub 2011 Dec 13.
9
Dynamics and non-canonical aspects of JAK/STAT signalling.JAK/STAT 信号转导的动力学和非经典方面。
Eur J Cell Biol. 2012 Jun-Jul;91(6-7):524-32. doi: 10.1016/j.ejcb.2011.09.005. Epub 2011 Oct 21.
10
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.JAK2 的假激酶结构域是一种双特异性蛋白激酶，可负向调节细胞因子信号转导。
Nat Struct Mol Biol. 2011 Aug 14;18(9):971-6. doi: 10.1038/nsmb.2099.