果蝇的JAK-STAT信号通路。

Zeidler Martin P, Bausek Nina

MRC Centre for Development and Biomedical Genetics and the Department of Biomedical Science; The University of Sheffield; Sheffield, UK.

JAKSTAT. 2013 Jul 1;2(3):e25353. doi: 10.4161/jkst.25353. Epub 2013 Aug 1.

The conservation of signaling cascades between humans and Drosophila, over more than 500 million years of evolutionary time, means that the genetic tractability of the fly can be used to its full advantage to understand the functional requirements for JAK-STAT pathway signaling across species. Here we review the background to how the pathway was first identified and the first characterization of JAK-STAT pathway phenotypes in the Drosophila system, highlighting the molecular, functional, and disease-related conservation of the pathway.

在超过5亿年的进化时间里，人类和果蝇之间信号级联的保守性意味着果蝇的遗传易处理性可以被充分利用，以了解跨物种JAK-STAT信号通路的功能需求。在这里，我们回顾该信号通路最初是如何被发现的背景，以及果蝇系统中JAK-STAT信号通路表型的首次特征描述，强调该信号通路在分子、功能和疾病方面的保守性。