State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Biological Science Research Center, Southwest University, Chongqing, China.
Front Immunol. 2021 Feb 23;12:613729. doi: 10.3389/fimmu.2021.613729. eCollection 2021.
Viral infection triggers insect immune response, including RNA interference, apoptosis and autophagy, and profoundly changes the gene expression profiles in infected cells. Although intracellular degradation is crucial for restricting viral infection, intercellular communication is required to mount a robust systemic immune response. This review focuses on recent advances in understanding the intercellular communications in insect antiviral immunity, including protein-based and virus-derived RNA based cell-cell communications, with emphasis on the signaling pathway that induces the production of the potential cytokines. The prospects and challenges of future work are also discussed.
病毒感染会触发昆虫的免疫反应，包括 RNA 干扰、细胞凋亡和自噬，并显著改变感染细胞的基因表达谱。尽管细胞内降解对于限制病毒感染至关重要，但细胞间通讯对于引发强大的系统免疫反应是必需的。本综述重点介绍了近年来在昆虫抗病毒免疫中细胞间通讯的研究进展，包括基于蛋白质和病毒衍生 RNA 的细胞间通讯，并强调了诱导潜在细胞因子产生的信号通路。还讨论了未来工作的前景和挑战。
